Evidence map›Paper›PMID 31094280›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020

Alterations in the retinal vasculature occur in multiple sclerosis and exhibit novel correlations with disability and visual function measures.

Olwen C Murphy, Ohemaa Kwakyi, Mustafa Iftikhar, Sidra Zafar, Jeffrey Lambe, Nicole Pellegrini, Elias S Sotirchos, Natalia Gonzalez-Caldito, Esther Ogbuokiri, Angeliki Filippatou and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Olwen C MurphyDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0001-7880-8948
Ohemaa KwakyiDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Mustafa IftikharWilmer Eye Institute, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Sidra ZafarWilmer Eye Institute, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Jeffrey LambeDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Nicole PellegriniDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Elias S SotirchosDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0002-8812-1637
Natalia Gonzalez-CalditoDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Esther OgbuokiriDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Angeliki FilippatouDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.ORCID 0000-0003-0419-233X
Hunter RisherDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Norah CowleyDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Sydney FeldmanDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Nicholas FioravanteDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Elliot M FrohmanDepartment of Neurology and Ophthalmology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Teresa C FrohmanDepartment of Neurology and Ophthalmology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Laura J BalcerLangone Medical Center, Department of Neurology, New York University, New York, NY, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Roomasa ChannaWilmer Eye Institute, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA/Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
Peter A CalabresiDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Shiv SaidhaDivision of Neuroimmunology and Neurological Infections, Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

backgroundThe retinal vasculature may be altered in multiple sclerosis (MS), potentially acting as a biomarker of disease processes.

objectiveTo compare retinal vascular plexus densities in people with MS (PwMS) and healthy controls (HCs), and examine correlations with visual function and global disability.

methodsIn this cross-sectional study, 111 PwMS (201 eyes) and 50 HCs (97 eyes) underwent optical coherence tomography angiography (OCTA). Macular superficial vascular plexus (SVP) and deep vascular plexus (DVP) densities were quantified, and poor quality images were excluded according to an artifact-rating protocol.

resultsMean SVP density was 24.1% (SD = 5.5) in MS eyes (26.0% (SD = 4.7) in non-optic neuritis (ON) eyes vs. 21.7% (SD = 5.5) in ON eyes,

conclusionsRetinal SVP density measured by OCTA is reduced across MS eyes, and correlates with visual function, EDSS, and MSFC scores.

Indexed as

AdultAngiographyCross-Sectional StudiesFemaleHumansMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingPersons with DisabilitiesRetinal VesselsSeverity of Illness IndexTomography, Optical CoherenceVision DisordersVisual AcuityangiographyMultiple sclerosisoptical coherence tomographyretinal vasculature

Identifiers

PMID31094280
PMCPMC6858526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.