Evidence map›Paper›PMID 31094098›Full record

ArticleCancer medicine2019

Racial differences in patterns of treatment among men diagnosed with de novo advanced prostate cancer: A SEER-Medicare investigation.

Jennifer L Beebe-Dimmer, Julie J Ruterbusch, Kathleen A Cooney, Adam Bolton, Kendra Schwartz, Ann G Schwartz, Elisabeth Heath

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Sociodemographic disparities in prostate cancer imaging.Abdominal radiology (New York) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Disparities With Systemic Therapies for Black Men Having Advanced Prostate Cancer: Where Do We Stand?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  12. Quality of life in the year after new diagnosis with advanced prostate cancer for Black and White individuals living in the US.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Reporting of Racial Health Disparities Research: Are We Making Progress?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jennifer L Beebe-DimmerBarbara Ann Karmanos Cancer Institute, Detroit, Michigan.ORCID 0000-0002-4320-739X
Julie J RuterbuschBarbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Kathleen A CooneyDuke University School of Medicine and Duke Cancer Institute, Durham, North Carolina.
Adam BoltonBarbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Kendra SchwartzBarbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Ann G SchwartzBarbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Elisabeth HeathBarbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Wayne State University · USDuke University · USThe Barbara Ann Karmanos Cancer Institute · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
NCI NIH HHS HHSN261201300011INCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

purposeApproximately 5% of men were initially diagnosed with (also referred to as de novo) advanced stage prostate cancer and experience far poorer survival compared to men diagnosed with local or regionally advanced disease. Given the number of new therapies targeting metastatic and castrate-resistant disease, we sought to describe recent treatment patterns by race for de novo AJCC stage IV prostate cancer.

methodsWe used Surveillance, Epidemiology, and End Results (SEER) data linked to Medicare files to identify men aged 66 and older diagnosed in 2004-2014 with advanced prostate cancer, and examined patterns of treatment among all patients and stratified by race/ethnicity.

resultsThere were 8828 eligible patients identified, and non-Hispanic black (NHB) patients were more likely to go without treatment (P < 0.001) compared to non-Hispanic white (NHW) patients, even after accounting for early mortality and TNM stage. The frequency of nearly all forms of treatment was lower among NHB with the exception of orchiectomy, which was significantly higher (10.1% vs 6.1%, P < 0.001), and the use of the progesterone Megace among Medicare Part D enrollees (24.6% vs 15.0%, P < 0.001).

conclusionsResults from this study of elderly Medicare patients presenting with advanced stage prostate cancer suggest that NHB men are less likely to pursue aggressive treatment options. With the reduction in screening for prostate cancer, presumably tied to USPSTF recommendations, and the increasing incidence of men diagnosed with de novo metastatic disease, understanding drivers of treatment-related decisions are critical in reducing racial disparities in advanced prostate cancer outcomes.

Indexed as

Delivery of Health CareHealthcare DisparitiesPractice Patterns, Physicians'AgedAged, 80 and overDisease ManagementHumansMaleMedicareNeoplasm MetastasisNeoplasm StagingProstatic NeoplasmsSEER ProgramUnited StatesAfrican AmericanAJCC Stage IVprostate cancertreatment disparities

Identifiers

PMID31094098
PMCPMC6558501
OpenAlexW2946827226

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.