Evidence map›Paper›PMID 31093979›Full record

ArticleThe Journal of physiology2019

Dynamic clamping human and rabbit atrial calcium current: narrowing I

Sarah Kettlewell, Priyanka Saxena, John Dempster, Michael A Colman, Rachel C Myles, Godfrey L Smith, Antony J Workman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Autonomic dysregulation and atrial arrhythmias.American journal of physiology. Cell physiology · 2025
    Review
  3. KFrontiers in physiology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Review
  13. Review
  14. Article
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah KettlewellInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.
Priyanka SaxenaInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.
John DempsterStrathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Michael A ColmanSchool of Biomedical Sciences, University of Leeds, Leeds, UK.ORCID 0000-0003-2817-8508
Rachel C MylesInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0003-4670-361X
Godfrey L SmithInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.
Antony J WorkmanInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-5429-8303
University of Glasgow · GBUniversity of Leeds · GBUniversity of Strathclyde · GB

Funding

British Heart Foundation PG/13/31/30156Medical Research Council MR/M014967/1Medical Research Council MR/M014967/2
6 · The paper itself

Abstract

key pointsEarly-afterdepolarizations (EADs) are abnormal action potential oscillations and a known cause of cardiac arrhythmias. Ventricular EADs involve reactivation of a Ca ABSTRACT: Atrial early-afterdepolarizations (EADs) may contribute to atrial fibrillation (AF), perhaps involving reactivation of L-type Ca

Indexed as

Action PotentialsAgedAnimalsAtrial FibrillationCalciumCalcium Channels, L-TypeCells, CulturedFemaleHeart AtriaHumansMaleMyocytes, CardiacPatch-Clamp TechniquesRabbitsCalciumCalcium Channels, L-TypeAfterdepolarisationsAtrial fibrillationAtrial myocyteCalcium window currentDynamic-clamp

Identifiers

PMID31093979
PMCPMC6767690
OpenAlexW2945093688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.