Evidence map›Paper›PMID 31093904›Full record

ArticleNeurochemical research2019

Ethanol Induces Sedation and Hypnosis via Inhibiting Histamine Release in Mice.

Zhangqing Ma, Wusan Wang, Tianxiao Wang, Wei Xu, Weiming Qu, Zhili Huang, Zongyuan Hong

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhangqing MaLaboratory of Quantitative Pharmacology, Department of Pharmacology, Wannan Medical College, Wuhu, 241002, China.
Wusan WangLaboratory of Quantitative Pharmacology, Department of Pharmacology, Wannan Medical College, Wuhu, 241002, China.
Tianxiao WangDepartment of Pharmacology, School of Basic Medical Sciences, and State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China.
Wei XuDepartment of Pharmacology, School of Basic Medical Sciences, and State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China.
Weiming QuDepartment of Pharmacology, School of Basic Medical Sciences, and State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China.
Zhili HuangDepartment of Pharmacology, School of Basic Medical Sciences, and State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China. huangzl@fudan.edu.cn.
Zongyuan HongLaboratory of Quantitative Pharmacology, Department of Pharmacology, Wannan Medical College, Wuhu, 241002, China. 19880003@wnmc.edu.cn.
State Key Laboratory of Medical NeurobiologyWannan Medical College · CNFudan University · CN

Funding

Anhui Science and Technology Department 1501041157National Natural Science Foundation of China 81171255National Natural Science Foundation of China 81671318
6 · The paper itself

Abstract

Ethanol is one of the most highly abused psychoactive compounds worldwide and induces sedation and hypnosis. The histaminergic system is involved in the regulation of sleep/wake function and is a crucial player in promoting wakefulness. To explore the role and mechanism of the histaminergic system in ethanol-induced sedation and hypnosis, we recorded locomotor activity (LMA) and electroencephalography (EEG)/electromyography (EMG) in mice using an infrared ray passive sensor recording system and an EEG/EMG recording system, respectively, after administration of ethanol. In vivo microdialysis coupled with high performance liquid chromatography and fluorometry technology were used to detect histamine release in the mouse frontal cortex (FrCx). The results revealed that ethanol significantly suppressed LMA of histamine receptor 1 (H

Indexed as

AnimalsDose-Response Relationship, DrugEthanolFrontal LobeHistamineHypnotics and SedativesLocomotionMice, Inbred C57BLMice, KnockoutReceptors, Histamine H1SleepWakefulnessEthanolHistamineHypnotics and SedativesReceptors, Histamine H1EthanolFrontal cortexHistamineSedation/hypnosis

Identifiers

PMID31093904
OpenAlexW2946738764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.