Evidence map›Paper›PMID 31093894›Full record

ArticleThe international journal of cardiovascular imaging2019

T1 reactivity as an imaging biomarker in myocardial tissue characterization discriminating normal, ischemic and infarcted myocardium.

Marly van Assen, Randy van Dijk, Dirkjan Kuijpers, Rozemarijn Vliegenthart, Matthijs Oudkerk

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Texture signatures of native myocardial TJournal of magnetic resonance imaging : JMRI · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marly van AssenCenter for Medical Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, EB 45, Groningen, The Netherlands.
Randy van DijkCenter for Medical Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, EB 45, Groningen, The Netherlands.
Dirkjan KuijpersDepartment of Cardiovascular Imaging, HMC-Bronovo, The Hague, The Netherlands.
Rozemarijn VliegenthartCenter for Medical Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, EB 45, Groningen, The Netherlands.
Matthijs OudkerkFaculty of Medical Sciences, University of Groningen, Groningen, The Netherlands. m.oudkerk@rug.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To demonstrate the potential for differentiating normal and diseased myocardium without Gadolinium using rest and stress T1-mapping. Patients undergoing 1.5T magnetic resonance imaging (MRI) as part of clinical work-up due to suspicion of coronary artery disease (CAD) were included. Adenosine stress perfusion MRI and late gadolinium enhancement (LGE) imaging were performed to identify ischemic and infarcted myocardium. Patients were retrospectively categorized into an ischemic, infarct and control group based on conventional acquisitions. Patient with both ischemic and infarcted myocardium were excluded. A total of 64 patients were included: ten with myocardial ischemia, 15 with myocardial infarction, and 39 controls. A native Modified Look-Locker Inversion Recovery (MOLLI) T1-mapping acquisition was performed at rest and stress. Pixel-wise myocardial T1-maps were acquired in short-axis view with inline motion-correction. Short-axis T1-maps were manually contoured using conservative septal sampling. Regions of interest were sampled in ischemic and infarcted areas detected on perfusion and LGE images. T1 reactivity was calculated as the percentage difference in T1 values between rest and stress. Remote myocardium was defined as myocardium without defects in the ischemic and infarcted group whereas normal myocardium is found in the control group only. Native T1-values were significantly higher in infarcted myocardium in rest and stress [median 1044 ms (interquartile range (IQR) 985-1076) and 1053 ms (IQR 989-1088)] compared to ischemic myocardium [median 961 ms (IQR 939-988) and 958 ms (IQR 945-988)]. T1-reactivity was significantly lower in ischemic and infarcted myocardium [median 0.00% (IQR - 0.18 to 0.16) and 0.41% (IQR 0.09-0.86)] compared to remote myocardium [median 3.54% (IQR 1.48-5.78) and 3.21% (IQR 1.95-4.79)]. Rest-stress T1-mapping is able to distinguish between normal, ischemic, infarcted and remote myocardium using native T1-values and T1-reactivity, and holds potential as an imaging biomarker for tissue characterization in MRI.

Indexed as

Magnetic Resonance Imaging, CineAdenosineAgedContrast MediaCoronary Artery DiseaseCoronary CirculationDiagnosis, DifferentialFemaleGadolinium DTPAHemodynamicsHumansMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaMyocardial Perfusion ImagingAdenosineContrast MediaGadolinium DTPAVasodilator AgentsAdenosineCAD—coronary artery diseaseCardiac MR—cardiac magnetic resonance imagingMOLLI—modified look-locker inversionNative T1-mapping

Identifiers

PMID31093894
PMCPMC6598951

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.