Evidence map›Paper›PMID 31093843›Full record

ArticleVirus genes2019

Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates.

Robert L Furler, Ayub Ali, Otto O Yang, Douglas F Nixon

Open access · greenAbstract read
In one paragraph

Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Identification of a small molecule for enhancing lentiviral transduction of T cells.Molecular therapy. Methods & clinical development · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Robert L FurlerDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 413 E 69th St., Belfer Research Building, New York, NY, 10021, USA. rlf2001@med.cornell.edu.ORCID http://orcid.org/0000-0001-5706-4871
Ayub AliDepartments of Microbiology, Immunology and Molecular Genetics, Medicine, and the UCLA AIDS Institute, University of California, 615 Charles E. Young Drive South, BSRB2, Los Angeles, CA, 90095, USA.
Otto O YangDepartments of Microbiology, Immunology and Molecular Genetics, Medicine, and the UCLA AIDS Institute, University of California, 615 Charles E. Young Drive South, BSRB2, Los Angeles, CA, 90095, USA.
Douglas F NixonDivision of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, 413 E 69th St., Belfer Research Building, New York, NY, 10021, USA.
Cornell University · USAIDS Healthcare Foundation · USBlack AIDS Institute · US

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
National Institute of Allergy and Infectious Diseases UM1AI126617National Science Foundation 1323522NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes. In this study, we infected primary human CD4

Indexed as

Gene Expression Regulation, ViralCD4-Positive T-LymphocytesCells, CulturedHIV-1Humansnef Gene Products, Human Immunodeficiency VirusVirus Replicationnef Gene Products, Human Immunodeficiency Virusnef protein, Human immunodeficiency virus 1Delta-NefHIV-1 NefHIV transcriptomicsRNA-Seq

Identifiers

PMID31093843
PMCPMC6640090
OpenAlexW2945700244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.