ArticleDigestive diseases and sciences2020
Acute Severe Ulcerative Colitis: The Oxford Criteria No Longer Predict In-Hospital Colectomy Rates.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Predictors for colectomy in patients with acute severe ulcerative colitis: a systematic review and meta-analysis.BMJ open gastroenterology · 2024Pooled it
- Managing Acute Severe Ulcerative Colitis in 2025 and Beyond.Current gastroenterology reports · 2026Review
- Short-term and long-term outcomes of acute severe ulcerative colitis in Taiwan: a multicenter study with pre- and post-biologics comparison.Intestinal research · 2026Article
- Efficacy and Safety of Tofacitinib for Acute Severe Ulcerative Colitis: A Systematic Review and Meta-Analysis.Gastroenterology research · 2025Article
- Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort.Angewandte Chemie (International ed. in English) · 2025Article
- Evaluation of Acute Severe Ulcerative Colitis Predictors for Steroid Therapy Refractoriness.Digestive diseases and sciences · 2025Article
- Clinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium.Alimentary pharmacology & therapeutics · 2024Review
- Extended Monitoring for Transition to Oral Corticosteroids in Acute Severe Ulcerative Colitis May Be Unnecessarily Prolonging Length of Stay.Digestive diseases and sciences · 2024Article
- Case report: Fecal microbiota transplant forFrontiers in immunology · 2024Article
- Biomarkers in inflammatory bowel disease: a practical guide.Therapeutic advances in gastroenterology · 2024Review
- Review article: Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies.United European gastroenterology journal · 2023Review
- Therapeutic advancement in inflammatory bowel disease by incorporating plant-based diet.Translational gastroenterology and hepatology · 2023Review
- Fecal Calprotectin Is a Predictor of Need for Rescue Therapy in Hospitalized Severe Colitis.Inflammatory bowel diseases · 2022Article
- Medical Treatment Options for Ulcerative Colitis.Clinics in colon and rectal surgery · 2022Review
- Role of Biomarkers in the Diagnosis and Treatment of Inflammatory Bowel Disease.Life (Basel, Switzerland) · 2021Review
- Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions.Clinical and experimental gastroenterology · 2021Review
- Concise Commentary: Second Line Is Not Second Best-Continuing Validity of the Oxford Criteria in the Management of Acute Severe Ulcerative Colitis.Digestive diseases and sciences · 2020Article
- Management of Acute Severe Colitis in the Era of Biologicals and Small Molecules.Journal of clinical medicine · 2019Review
- Upadacitinib Was Administered as a Sequential Salvage Therapy for Acute Severe Ulcerative Colitis: A Case Report.Case reports in gastroenterologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients admitted to hospital with acute severe ulcerative colitis have a short-term in-hospital colectomy rate of 30%. The Oxford criteria state that if the CRP is greater than 45 mg/l or there are more than eight bowel movements in 24 h at day 3 of intravenous corticosteroids, there is an 85% risk of an in-hospital colectomy.
aimThe aim of this study was to determine whether this high rate of colectomy continues to be accurate in this medically refractory patient population.
methodsWe performed a retrospective chart review of 80 patients admitted to a tertiary hospital between 2013 and 2017 with acute severe ulcerative colitis.
resultsSixteen (20%) patients required an in-hospital colectomy. Of the 33 patients that fulfilled the Oxford criteria, 12 (36%) patients required a colectomy during admission. Only four (9.5%) patients who did not fulfill the Oxford criteria required a colectomy during admission. Twenty-two patients that had fulfilled the Oxford criteria received infliximab as second-line medical therapy.
conclusionIn a patient population that fulfilled the Oxford criteria, the in-hospital colectomy rate has reduced from 85% in 1996 to 36% in 2017. These results should be considered when discussing with patients the opportunity to commence infliximab or cyclosporine as second-line medical therapy.
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