ArticleInternational ophthalmology2019
Local allergic conjunctivitis: a phenotype of allergic conjunctivitis.
Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Clinical Effect of Bacterial Suspension in Patients with Moderate-to-Severe Allergic Conjunctivitis.Journal of clinical medicine · 2026Article
- Ocular Allergy Within the Framework of the EAACI Nomenclature of Allergic Diseases and Hypersensitivity Reactions.Allergy, asthma & immunology research · 2026Review
- Evaluation on the clinical findings and allergological factors of local allergic conjunctivitis and non-local allergic conjunctivitis.Scientific reports · 2025Article
- Allergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy.Clinical reviews in allergy & immunology · 2024Review
- JACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease.Scientific reports · 2024Article
- A nerve-goblet cell association promotes allergic conjunctivitis through rapid antigen passage.JCI insight · 2023Article
- Neuronal-Immune Cell Units in Allergic Inflammation in the Nose.International journal of molecular sciences · 2022Review
- Epithelial barrier dysfunction in ocular allergy.Allergy · 2022Review
- Aqueous-Deficient Dry Eye Exacerbates Signs and Symptoms of Allergic Conjunctivitis in Mice.International journal of molecular sciences · 2022Article
- Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis.Clinical and translational allergy · 2022Article
- Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis.Journal of neuroinflammation · 2022Article
- Relationship among total tear IgE, specific serum IgE, and total serum IgE levels in patients with pollen-induced allergic conjunctivitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs.Journal of gastroenterology · 2021Observational
- Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Allergen Immunotherapy for Local Respiratory Allergy.Current allergy and asthma reports · 2020Review
- The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis.Journal of ophthalmology · 2020Review
- How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians.Journal of clinical medicine · 2019Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLocal allergic rhinitis (LAR) has been reported in the field of otolaryngology; however, the concept of local allergic conjunctivitis (LAC) has not been widely studied in the ophthalmologic community. We routinely examined total IgE levels in tear fluids (t-tIgE) and antigen-specific IgE levels in serum (s-sIgE) in patients with suspected allergic conjunctivitis, on the basis of Japanese guidelines for allergic conjunctival diseases. There are several cases in which the results of t-tIgE and s-sIgE testing are divergent. We suggest that these divergent cases correspond to LAR in otolaryngology.
methodsThe study included 148 patients (33 men and 115 women) with clinical symptoms and signs of allergic conjunctivitis. Allerwatch Tear IgE
resultsA total of 83 patients (56.1%) were positive and 65 patients were negative for t-tIgE in the AW. In the ICR, 97 patients (65.5%) were positive for at least one of the eight allergens, whereas 51 (34.5%) were negative for all allergens. Among 83 patients positive for t-tIgE, 14 (16.9%) had no detectable s-sIgE. Therefore, we considered the possibility of LAC in cases in which only local IgE could be detected. Among 28 cases (18.9%) who were negative for t-tIgE and s-sIgE, 21 underwent conjunctival scraping; eosinophils were found in four cases and eosinophilic granules in two. Accordingly, we considered the possibility of non-IgE-type AC in these six cases.
conclusionsThese results suggest the existence of LAC that is a candidate of a phenotype of AC.
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