Evidence map›Paper›PMID 31093748›Full record

ArticleSurgical endoscopy2020

Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: a multi-centre propensity score-based analysis.

Takeo Nomi, Fumitoshi Hirokawa, Masaki Kaibori, Masaki Ueno, Shogo Tanaka, Daisuke Hokuto, Takehiro Noda, Takuya Nakai, Hisashi Ikoma, Hiroya Iida and 9 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 5 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Guideline
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  5. [Evidence of minimally invasive oncological surgery of the liver].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021
    Pooled it
  6. Impact of CGA and Surgical Risk Calculator before elective cancer surgery on postoperative delirium in elderly patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Observational
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  19. Impact of liver cirrhosis and portal hypertension on minimally invasive limited liver resection for primary liver malignancies in the posterosuperior segments: An international multicenter study.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Takeo NomiDepartment of Surgery, Nara Medical University, 840, Shijocho, Kashihara, Nara, 634-8522, Japan. nomi@naramed-u.ac.jp.
Fumitoshi HirokawaDepartment of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Osaka, Japan.
Masaki KaiboriDepartment of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan.
Masaki UenoSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Shogo TanakaDepartment of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Daisuke HokutoDepartment of Surgery, Nara Medical University, 840, Shijocho, Kashihara, Nara, 634-8522, Japan.
Takehiro NodaDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Takuya NakaiDepartment of Surgery, Faculty of Medicine, Kindai University, Osakasayama, Osaka, Japan.
Hisashi IkomaDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hiroya IidaDivision of Gastrointestinal, Breast, and General Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga Prefecture, Japan.
Koji KomedaDepartment of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Osaka, Japan.
Morihiko IshizakiDepartment of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan.
Shinya HayamiSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Masataka MatsumotoDepartment of Surgery, Faculty of Medicine, Kindai University, Osakasayama, Osaka, Japan.
Ryo MorimuraDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hiromitsu MaehiraDivision of Gastrointestinal, Breast, and General Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga Prefecture, Japan.
Masayuki ShoDepartment of Surgery, Nara Medical University, 840, Shijocho, Kashihara, Nara, 634-8522, Japan.
Shoji KuboDepartment of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Nara Medical University · JPKansai Medical University · JPKindai University · JPKyoto Prefectural University of Medicine · JPOsaka City University · JPOsaka Medical and Pharmaceutical University · JPOsaka University · JPShiga University of Medical Science · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe frequency of liver resection in elderly patients has been increasing. However, data are limited regarding the safety of laparoscopic liver resection (LLR) compared with that of open liver resection (OLR) for hepatocellular carcinoma (HCC) in elderly patients. The present study aimed to compare short-term outcomes between LLR and OLR in elderly patients with HCC using propensity score matching.

methodsThe study included 630 patients (age, ≥ 75 years) who underwent liver resection for HCC at nine liver centres between April 2010 and December 2017. Patients were divided into LLR and OLR groups, and perioperative outcomes were compared between the groups. In addition, subgroup analysis was performed according to age (75-79 and ≥ 80 years).

resultsOf the 630 patients, 221 and 409 were included in the LLR and OLR groups, respectively. After propensity score matching, 155 patients were included in each group. Intraoperative blood loss and the transfusion, post-operative overall complication and major complication rates were lower in the matched LLR than the matched OLR group (P < 0.001, P = 0.004, P < 0.001 and P < 0.001, respectively). Moreover, post-operative pulmonary and cardiovascular complications were less frequent in the matched LLR group (P = 0.008 and P = 0.014, respectively). In subgroup analysis, among octogenarians, the post-operative major complication rate was lower and hospital stay was shorter in the matched LLR than the matched OLR group (P < 0.001 and P < 0.001, respectively).

conclusionLLR for HCC is associated with good short-term outcomes in patients aged ≥ 75 years compared with OLR. LLR is safe and feasible in selected octogenarians with HCC.

Indexed as

Propensity ScoreAgedAged, 80 and overBlood Loss, SurgicalCarcinoma, HepatocellularFemaleHepatectomyHumansIncidenceJapanLaparoscopyLength of StayLiver NeoplasmsMalePostoperative ComplicationsRetrospective StudiesAgeingElderlyHepatocellular carcinomaLaparoscopic liver resectionPropensity score matching

Identifiers

PMID31093748
OpenAlexW2944993008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.