Evidence map›Paper›PMID 31093743›Full record

ReviewClinical oral investigations2019

Matrix metalloproteinases and inhibitors in dentistry.

Gerd-Jan Boelen, Lucas Boute, Joëy d'Hoop, Mostafa EzEldeen, Ivo Lambrichts, Ghislain Opdenakker

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gerd-Jan BoelenDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium.
Lucas BouteDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium.
Joëy d'HoopDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium.
Mostafa EzEldeenDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium.
Ivo LambrichtsBiomedical Research Institute, Hasselt University, Diepenbeek, Belgium.
Ghislain OpdenakkerDepartment of Oral Health Sciences, KU Leuven, Leuven, Belgium. ghislain.opdenakker@rega.kuleuven.be.ORCID http://orcid.org/0000-0003-1714-2294
KU Leuven · BEHasselt University · BERega Institute for Medical Research · BE

Funding

Concerted Action C1 grant from KU Leuven grant C16/17/010Research Foundation of Flanders (FWO-Vlaanderen) project 72015N
6 · The paper itself

Abstract

objectivesMatrix metalloproteinase (MMP) expression has been associated with tissue development, invasive cancer cell behavior, and inflammation. The associations of increased expression of MMPs with diseases have led to intensive research activities to develop MMP inhibitors. Here, the questions are addressed which associations between increased levels of any MMP with dental diseases may be cause or consequence, whether MMP levels may be of diagnostic value and whether and which MMP inhibitors need further investigations for use in dental diseases.

methodsTo study the role of MMPs and to discriminate between cause or consequence, the literature about measurements of MMPs and about the use of inhibitory drugs and genetic knockout animal models in dentistry was compared.

resultsThe only FDA-approved treatment with MMP inhibitors is tetracyclines for periodontitis, whereas a diagnostic test for activated MMP-8 in oral fluids is valued in practical periodontology. The MMP literature in dentistry is artificially skewed to the gelatinases MMP-2 and MMP-9 and to enamelysin, alias MMP-20. The basis for this observation is, respectively, the widely used and sensitive technique of gelatin zymography and enamel proteins as substrates of MMP-20. Studies on additional MMPs are gaining interest in dentistry and MMP inhibitors may provide new applications. In addition, drugs with proven effects for the treatment of dental diseases may be found to act through MMP inhibition. CONCLUSION AND RELEVANCE: In conclusion, research on MMPs and inhibitors may provide practical applications beyond diagnosis and treatment of periodontitis and will be, directly or indirectly, beneficial for patients with dental or periodontal diseases.

Indexed as

Matrix Metalloproteinase InhibitorsPeriodontitisAnimalsDentistryHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsInhibitorMatrix metalloproteinasePeriodontitis

Identifiers

PMID31093743
OpenAlexW2944906498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.