ArticleMicrobial ecology2020
Probiotics Modulate a Novel Amphibian Skin Defense Peptide That Is Antifungal and Facilitates Growth of Antifungal Bacteria.
Article in Microbial ecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 78 citations in OpenAlex.
- Changes to Skin Microbiome Community Dynamics Support Resistance to Enzootic and Epizootic Strains of Batrachochytrium dendrobatidis (Bd) in the Spotted Salamander (Ambystoma maculatum).Molecular ecology · 2026Article
- Captive environment induced greater physiological changes than probiotic treatment in Pelophylax nigromaculatus.PloS one · 2026Article
- Advancing the study of microbial symbionts of amphibians and reptiles.Frontiers in amphibian and reptile science · 2026Article
- Identification of Opportunistic Pathogens on the Skin of Salamanders for Use as Molecular Targets of a De Novo Design of Multitarget Anti-International journal of microbiology · 2026Article
- Novel antimicrobial peptides and peptide-microbiome crosstalk in Appalachian salamander skin.NPJ biofilms and microbiomes · 2025Article
- Microbial responses to antibiotics cryptically shift the direction of disease outcomes.Scientific reports · 2025Article
- Probiotic colonization ofInfection and immunity · 2025Article
- Effects of snake fungal disease (ophidiomycosis) on the skin microbiome across two major experimental scales.Conservation biology : the journal of the Society for Conservation Biology · 2025Article
- Double-edged effects of aquatic environmental biofilms onISME communications · 2025Article
- The impact of microbiome diversity and composition on host health and susceptibility to disease across amphibian life stages.Frontiers in amphibian and reptile science · 2025Article
- Skin microbiomes of frogs vary among body regions, revealing differences that reflect known patterns of chytrid infection.Frontiers in microbiology · 2025Article
- The role of family and environment in determining the skin bacterial communities of captive aquatic frogs, Xenopus laevis.FEMS microbiology ecology · 2024Article
- Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics.International journal of molecular sciences · 2024Review
- Priority effects alter microbiome composition and increase abundance of probiotic taxa in treefrog tadpoles.Applied and environmental microbiology · 2024Article
- Transport from the wild rapidly alters the diversity and composition of skin microbial communities and antifungal taxa in spring peeper frogs.Frontiers in microbiomes · 2024Article
- Skin microbiota during metamorphosis ofFrontiers in microbiology · 2024Article
- Gene functions of theMicrobial genomics · 2024Article
- When the host's away, the pathogen will play: the protective role of the skin microbiome during hibernation.Animal microbiome · 2023Review
- Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome.iScience · 2023Article
- The adaptive microbiome hypothesis and immune interactions in amphibian mucus.Developmental and comparative immunology · 2023Review
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
Probiotics can ameliorate diseases of humans and wildlife, but the mechanisms remain unclear. Host responses to interventions that change their microbiota are largely uncharacterized. We applied a consortium of four natural antifungal bacteria to the skin of endangered Sierra Nevada yellow-legged frogs, Rana sierrae, before experimental exposure to the pathogenic fungus Batrachochytrium dendrobatidis (Bd). The probiotic microbes did not persist, nor did they protect hosts, and skin peptide sampling indicated immune modulation. We characterized a novel skin defense peptide brevinin-1Ma (FLPILAGLAANLVPKLICSITKKC) that was downregulated by the probiotic treatment. Brevinin-1Ma was tested against a range of amphibian skin cultures and found to inhibit growth of fungal pathogens Bd and B. salamandrivorans, but enhanced the growth of probiotic bacteria including Janthinobacterium lividum, Chryseobacterium ureilyticum, Serratia grimesii, and Pseudomonas sp. While commonly thought of as antimicrobial peptides, here brevinin-1Ma showed promicrobial function, facilitating microbial growth. Thus, skin exposure to probiotic bacterial cultures induced a shift in skin defense peptide profiles that appeared to act as an immune response functioning to regulate the microbiome. In addition to direct microbial antagonism, probiotic-host interactions may be a critical mechanism affecting disease resistance.
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Registered trials
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