ArticleDiabetologia2019
Urinary bisphenol A concentration and glucose homeostasis in non-diabetic adults: a repeated-measures, longitudinal study.
Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Urinary bisphenol exposure and risk of type 1 diabetes and glycemic traits in Chinese children: a case-control study.Frontiers in nutrition · 2026Article
- Food Packaging and Chemical Migration: A Food Safety Perspective.Journal of food science · 2025Review
- Article
- Whole Blood-based Transcriptional Risk Score for Nonobese Type 2 Diabetes Predicts Dynamic Changes in Glucose Metabolism.The Journal of clinical endocrinology and metabolism · 2023Article
- Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases.Journal of xenobiotics · 2023Review
- Risk Factors for Diabetes and Cardiovascular Complications in the Chinese Population.China CDC weekly · 2023Article
- Food contaminants and potential risk of diabetes development: A narrative review.World journal of diabetes · 2023Review
- Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus.American journal of physiology. Endocrinology and metabolism · 2023Review
- Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review.Heliyon · 2023Review
- Protective effects of polyphenols against endocrine disrupting chemicals.Food science and biotechnology · 2022Review
- Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case-control study.Clinical epigenetics · 2021Article
- The Role of the Bisphenol A in Diabetes and Obesity.Biomedicines · 2021Review
- Stronger association of triglyceride glucose index than the HOMA-IR with arterial stiffness in patients with type 2 diabetes: a real-world single-centre study.Cardiovascular diabetology · 2021Article
- Bisphenol A and Type 2 Diabetes Mellitus: A Review of Epidemiologic, Functional, and Early Life Factors.International journal of environmental research and public health · 2021Review
- The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability.International journal of environmental research and public health · 2019Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisBisphenol A (BPA) has been shown to be potentially associated with type 2 diabetes; however, there is little evidence associating BPA exposure with glucose metabolic outcomes prior to diabetes onset. We aimed to examine BPA exposure in relation to glucose homeostasis among non-diabetic individuals.
methodsThis longitudinal cohort study comprised 2336 Chinese adults aged 40 years or above (62.8% women) and free of diabetes at baseline in 2009, followed for 4 years. Urinary BPA and glucose metabolic traits including fasting plasma glucose (FPG), 2 h post-load plasma glucose, fasting serum insulin, HOMA-IR and HOMA-B were measured at baseline and follow-up. Repeated-measures analysis was performed to evaluate associations of urinary BPA concentration with markers of glucose homeostasis.
resultsAfter full adjustment for confounders including BMI, each tenfold increase in urinary BPA concentrations was associated with a 3.39% increase in FPG (95% CI 2.24%, 4.55%) and an 11.6% decrease in HOMA-B (95% CI -15.8%, -7.18%) in women. The inverse association between urinary BPA and HOMA-B was more prominent among overweight or obese individuals (change -13.7%; 95% CI -19.3%, -7.61%) compared with those who were of normal weight (change -6.74%; 95% CI -13.2%, 0.20%) (p CONCLUSIONS/
interpretationOur findings suggest that exposure to BPA was independently associated with impaired glucose homeostasis before the development of diabetes in middle-aged and elderly women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.