Evidence map›Paper›PMID 31093570›Full record

ReviewDiagnostic and prognostic research2018

Dynamic models to predict health outcomes: current status and methodological challenges.

David A Jenkins, Matthew Sperrin, Glen P Martin, Niels Peek

Abstract readReview
In one paragraph

Review in Diagnostic and prognostic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Exploring the role of health-related quality of life measures in predictive modelling for oncology: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
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  6. Review
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  13. Recommendations for Validating Omics Prediction Models: Insights from a Lung Cancer RNA Biomarker Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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  20. tdCoxSNN: Time-dependent Cox survival neural network for continuous-time dynamic prediction.Journal of the Royal Statistical Society. Series C, Applied statistics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David A Jenkins1Health e-Research Centre, Farr Institute, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.ORCID 0000-0001-6687-3507
Matthew Sperrin1Health e-Research Centre, Farr Institute, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Glen P Martin1Health e-Research Centre, Farr Institute, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Niels Peek1Health e-Research Centre, Farr Institute, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisease populations, clinical practice, and healthcare systems are constantly evolving. This can result in clinical prediction models quickly becoming outdated and less accurate over time. A potential solution is to develop 'dynamic' prediction models capable of retaining accuracy by evolving over time in response to observed changes. Our aim was to review the literature in this area to understand the current state-of-the-art in dynamic prediction modelling and identify unresolved methodological challenges.

methodsMEDLINE, Embase and Web of Science were searched for papers which used or developed dynamic clinical prediction models. Information was extracted on methods for model updating, choice of update windows and decay factors and validation of models. We also extracted reported limitations of methods and recommendations for future research.

resultsWe identified eleven papers that discussed seven dynamic clinical prediction modelling methods which split into three categories. The first category uses frequentist methods to update models in discrete steps, the second uses Bayesian methods for continuous updating and the third, based on varying coefficients, explicitly describes the relationship between predictors and outcome variable as a function of calendar time. These methods have been applied to a limited number of healthcare problems, and few empirical comparisons between them have been made.

conclusionDynamic prediction models are not well established but they overcome one of the major issues with static clinical prediction models, calibration drift. However, there are challenges in choosing decay factors and in dealing with sudden changes. The validation of dynamic prediction models is still largely unexplored terrain.

Indexed as

CalibrationDynamic modelsPrediction modelsValidation

Identifiers

PMID31093570
PMCPMC6460710

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.