Evidence map›Paper›PMID 31093549›Full record

ReviewDiagnostic and prognostic research2017

Tufts PACE Clinical Predictive Model Registry: update 1990 through 2015.

Benjamin S Wessler, Jessica Paulus, Christine M Lundquist, Muhammad Ajlan, Zuhair Natto, William A Janes, Nitin Jethmalani, Gowri Raman, Jennifer S Lutz, David M Kent

Abstract readReview
In one paragraph

Review in Diagnostic and prognostic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  14. Model-Based ROC Curve: Examining the Effect of Case Mix and Model Calibration on the ROC Plot.Medical decision making : an international journal of the Society for Medical Decision Making · 2022
    Article
  15. Article
  16. A Framework for Using Real-World Data and Health Outcomes Modeling to Evaluate Machine Learning-Based Risk Prediction Models.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin S Wessler1Division of Cardiology, Tufts Medical Center, Boston, USA.
Jessica Paulus2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
Christine M Lundquist2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
Muhammad Ajlan2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
Zuhair Natto2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
William A Janes2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
Nitin Jethmalani2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
Gowri Raman4Center for Clinical Evidence Synthesis, ICRHPS, Medical Center/Tufts University School of Medicine, Boston, USA.
Jennifer S Lutz2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.
David M Kent2Predictive Analytics and Comparative Effectiveness (PACE) Center, Institute for Clinical Research and Health Policy Studies (ICRHPS), Tufts Medical Center/Tufts University School of Medicine, 800 Washington Street, Box 63, Boston, MA 02111 USA.

Funding

Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
Training Program in Cardiovascular ResearchT32HL069770 · NHLBI · TUFTS MEDICAL CENTER · PI KARAS, RICHARD H · 2003 to 2013
$4.7M
Value of Personalized Risk InformationU01NS086294 · NINDS · TUFTS MEDICAL CENTER · PI KENT, DAVID M, NEUMANN, PETER · 2013 to 2017
$2.6M
NCATS NIH HHS UL1 TR001064NHLBI NIH HHS T32 HL069770NINDS NIH HHS U01 NS086294
6 · The paper itself

Abstract

backgroundClinical predictive models (CPMs) estimate the probability of clinical outcomes and hold the potential to improve decision-making and individualize care. The Tufts Predictive Analytics and Comparative Effectiveness (PACE) CPM Registry is a comprehensive database of cardiovascular disease (CVD) CPMs. The Registry was last updated in 2012, and there continues to be substantial growth in the number of available CPMs.

methodsWe updated a systematic review of CPMs for CVD to include articles published from January 1990 to March 2015. CVD includes coronary artery disease (CAD), congestive heart failure (CHF), arrhythmias, stroke, venous thromboembolism (VTE), and peripheral vascular disease (PVD). The updated Registry characterizes CPMs based on population under study, model performance, covariates, and predicted outcomes.

resultsThe Registry includes 747 articles presenting 1083 models, including both prognostic (

conclusionsThere is substantial redundancy of CPMs for a wide spectrum of CVD conditions. While the number of CPMs continues to increase, model performance is often inadequately reported and calibration is infrequently assessed. More work is needed to understand the potential impact of this literature.

Indexed as

Cardiovascular disease risk factorsCerebrovascular disease/strokeClinical predictive modelCoronary artery diseaseMethodsModelingPredictionPrognostic factorRisk stratification

Identifiers

PMID31093549
PMCPMC6460840

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.