Evidence map›Paper›PMID 31093538›Full record

ArticleDiagnostic and prognostic research2017

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study.

John Allotey, Nadine Marlin, Ben W Mol, Peter Von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Asif Ahmed, Jane Daniels, Jon Deeks, Khaled Ismail and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic and prognostic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

John Allotey1Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nadine Marlin2Pragmatic Clinical Trials Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ben W Mol4The Robinson Research Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia.
Peter Von Dadelszen5Institute of Cardiovascular and Cell Sciences, St George's, University of London, London, UK.
Wessel Ganzevoort6Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands.
Joost Akkermans7Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
Asif Ahmed8Aston Medical School, Aston University, Birmingham, UK.
Jane Daniels9University of Birmingham Clinical Trials Unit, Edgbaston, Birmingham, UK.
Jon Deeks10School of Health and Population Sciences, University of Birmingham, Birmingham, UK.
Khaled Ismail11Birmingham Centre for Women's and Children's Health, University of Birmingham, Birmingham, UK.
Ann Marie BarnardAction on Pre-eclampsia (APEC) Charity, Evesham, Worcestershire UK.
Julie Dodds1Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Sally Kerry2Pragmatic Clinical Trials Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Carl Moons13Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands.
Khalid S Khan1Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Richard D Riley14Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK.
Shakila Thangaratinam1Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Queen Mary University of London · GBUniversity of Birmingham · GBAcademic Medical Center · NLAston University · GBCancer Research UK Clinical Trials Unit · GBKeele University · GBLeiden University Medical Center · NLSt George's, University of London · GBUniversity Medical Center Utrecht · NLUniversity of Adelaide · AU

Funding

Department of Health 09/22/163
6 · The paper itself

Abstract

backgroundEarly-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management.

methodsWe aim to undertake a multicentre prospective cohort study (Prediction of Risks in Early onset Pre-eclampsia (PREP)) to develop clinical prediction models in women with early-onset pre-eclampsia, for risk of adverse maternal outcomes by 48 h and by discharge. We will externally validate the models in two independent cohorts with 634 and 216 women. In the secondary analyses, we will assess risk of adverse fetal and neonatal outcomes at birth and by discharge. DISCUSSION: The PREP study will quantify the risk of maternal complications at various time points and provide individualised estimates of overall risk in women with early-onset pre-eclampsia to plan the management.

trial registrationISRCTN registry, ISRCTN40384046.

Indexed as

Complication riskEarly-onset pre-eclampsiaFetalMaternalPrediction modelPrognosis

Identifiers

PMID31093538
PMCPMC6457143
OpenAlexW2587207001

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.