ArticleScience advances2019
Triggered reversible substitution of adaptive constitutional dynamic networks dictates programmed catalytic functions.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A Programmed DNA Dynamic Assembly-Guided Molecular Amplifier for Authentic Information Decryption.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Covalent Dynamic DNA Networks to Translate Multiple Inputs into Programmable Outputs.Journal of the American Chemical Society · 2025Article
- Dynamic DNA Networks-Guided Directional and Orthogonal Transient Biocatalytic Cascades.Journal of the American Chemical Society · 2023Article
- PhotocleavableChemical reviews · 2023Review
- A DNA Finite-State Machine Based on the Programmable Allosteric Strategy of DNAzyme.International journal of molecular sciences · 2023Article
- DNA Assembly-Based Stimuli-Responsive Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Cascade Strand Displacement and Bipedal Walking Based DNA Logic System for miRNA Diagnostics.ACS central science · 2021Article
- Functional Constitutional Dynamic Networks Revealing Evolutionary Reproduction/Variation/Selection Principles.Journal of the American Chemical Society · 2020Article
- A supramolecular aggregation-based constitutional dynamic network for information processing.Chemical science · 2020Article
- Enzyme-Guided Selection and Cascaded Emergence of Nanostructured Constitutional Dynamic Networks.Nano letters · 2020Article
- Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine.Biomacromolecules · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The triggered substitution of networks and their resulting functions play an important mechanism in biological transformations, such as intracellular metabolic pathways and cell differentiation. We describe the triggered, cyclic, reversible intersubstitution of three nucleic acid-based constitutional dynamic networks (CDNs) and the programmed catalytic functions guided by the interconverting CDNs. The transitions between the CDNs are activated by nucleic acid strand displacement processes acting as triggers and counter triggers, leading to the adaptive substitution of the constituents and to emerging catalytic functions dictated by the compositions of the different networks. The quantitative evaluation of the compositions of the different CDNs is achieved by DNAzyme reporters and complementary electrophoresis experiments. By coupling a library of six hairpins to the interconverting CDNs, the CDN-guided, emerging, programmed activities of three different biocatalysts are demonstrated. The study has important future applications in the development of sensor systems, finite-state logic devices, and selective switchable catalytic assemblies.
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