ArticleMediators of inflammation2019
Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessing the evidence for health benefits of low-level weight loss: a systematic review.International journal of obesity (2005) · 2025Pooled it
- Alpha-lipoic acid effect on leptin and adiponectin concentrations: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical pharmacology · 2020Pooled it
- The transtheoretical model is an effective weight management intervention: a randomized controlled trial.BMC public health · 2020Trial
- Review
- Review
- Association of adipokines with insulin resistance and metabolic syndrome including obesity and diabetes.GHM open · 2023Review
- Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus?World journal of diabetes · 2022Review
- Adipokines Profile and Inflammation Biomarkers in Prepubertal Population with Obesity and Healthy Metabolic State.Children (Basel, Switzerland) · 2022Article
- Prediction of Metabolic Disorders Using NMR-Based Metabolomics: The Shanghai Changfeng Study.Phenomics (Cham, Switzerland) · 2021Article
- Calorie Restriction With Exercise Intervention Improves Inflammatory Response in Overweight and Obese Adults: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2021Review
- Metabolically Healthy Obesity: Presence of Arterial Stiffness in the Prepubescent Population.International journal of environmental research and public health · 2020Article
- Association of Lifestyle and Body Composition on Risk Factors of Cardiometabolic Diseases and Biomarkers in Female Adolescents.Mediators of inflammation · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFor the metabolically healthy obese (MHO) subjects, it is unclear whether weight loss provides cardiometabolic benefits. Our objective was to evaluate whether changes in adipokine and inflammatory biomarker levels were related to lifestyle modification (with Mediterranean diet and physical exercise program).
methods115 women (35-55 years) with BMI of 30-40 kg/m
resultsThe final sample comprised 67 women. 23 (38.3%) lost <5%, 22 (36.7%) lost ≥5%-<10%, and 22 (36.7%) lost ≥10% of baseline weight. After 2 years, in Group 1, adiponectin, hsCRP, IL-6, and TNFa decreased (-1.2 ng/ml,
conclusionWeight loss reduces inflammatory biomarkers in the MHO but induces a deterioration in the adipokine profile, which does not improve with diet and exercise intervention. These findings allow us to clarify mechanisms behind inflammation and metabolic disorder genesis so as to prevent development of obesity-associated comorbidities.
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