Evidence map›Paper›PMID 31092995›Full record

ArticleIndian journal of clinical biochemistry : IJCB2019

MicroRNA-183-5p: A New Potential Marker for Prostate Cancer.

Mohammad Waseem, Mohammad Kaleem Ahmad, Mohammad Serajuddin, Ved Bhaskar, Satya Narain Sankhwar, Abbas Ali Mahdi

Abstract read
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. MicroRNA Dysregulation in Prostate Cancer.Pharmacogenomics and personalized medicine · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2.Computational and mathematical methods in medicine · 2021
    Article
  19. MicroRNA-183 in Cancer Progression.Journal of Cancer · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Waseem1Molecular and Cell Biology, Department of Biochemistry, King George's Medical University, Lucknow, U.P. 226003 India.
Mohammad Kaleem Ahmad1Molecular and Cell Biology, Department of Biochemistry, King George's Medical University, Lucknow, U.P. 226003 India.
Mohammad Serajuddin3Department of Zoology, Lucknow University, Lucknow, U.P. 226007 India.
Ved Bhaskar2Department of Urology, King George's Medical University, Lucknow, U.P. 226003 India.
Satya Narain Sankhwar2Department of Urology, King George's Medical University, Lucknow, U.P. 226003 India.
Abbas Ali Mahdi1Molecular and Cell Biology, Department of Biochemistry, King George's Medical University, Lucknow, U.P. 226003 India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microRNA (miR)-183-5p is expressed at high level in the majority of cancer. The purpose of present study was to investigate the role of oncogenic miR-183-5p in prostate cancer (PCa) as biomarker. We carried out our experiment in 50 prostate cancer patients and 40 patients of benign prostatic hyperplasia (BPH) and 40 adjacent controls tissue. The expression of miR-183-5p was evaluated through reverse transcription qualitative polymerase chain reaction. We found that the expression of miR-183-5p in PCa tissue was significantly up regulated as compared to BPH patients and adjacent normal tissues as control. Additionally, miR-183 expression was correlated with higher prostate-specific antigen, higher Gleason Score and metastatic condition. A receiver operating characteristic curve analysis revealed that miR-183-5p distinguished PCa patients from BPH patients and also from control. In conclusion, our data suggest that oncogenic miR-183-5p may be useful as a new tissue specific diagnostic biomarker in prostate cancer.

Indexed as

BPHMicroRNAProstate cancerRT-PCR and diagnosis

Identifiers

PMID31092995
PMCPMC6486929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.