ArticleIndian journal of clinical biochemistry : IJCB2019
Silymarin Attenuates ELMO-1 and KIM-1 Expression and Oxidative Stress in the Kidney of Rats with Type 2 Diabetes.
Article in Indian journal of clinical biochemistry : IJCB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06801886 (Effect of Silymarin Supplementation on Graft Function and Early Post-transplant Complications), which is not on this map. Cited by 6 papers.
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Effect of Silymarin Supplementation on Graft Function and Early Post-transplant Complications
Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- TFAP2A-mediated Transcriptional Activation of ELMO1 Inhibits Ferroptosis and Promotes Esophageal Squamous Cell Carcinoma Progression.Molecular biotechnology · 2026Article
- Clinicobiochemical and gas chromatography-mass spectrometry-based serum metabolomics for determining the therapeutic efficacy of silymarin in pneumonic Barki sheep.Open veterinary journal · 2025Article
- Nephroprotective Effect ofACS omega · 2024Article
- Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats.Scientific reports · 2022Article
- Effect of miR-132-3p on sepsis-induced acute kidney injury in mice via regulating HAVCR1/KIM-1.American journal of translational research · 2021Article
- Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes.Iranian journal of basic medical sciences · 2019Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Chronic diabetes mellitus is accompanied with overexpression of ELMO1 and KIM1 and enhanced oxidative stress. This study was aimed to evaluate the effects of administration of silymarin on oxidative stress markers and ELMO1 and KIM1 expression in the kidney tissue of type 2 diabetic rats. In this experimental study, 36 male Wistar rats were divided into 6 groups: Control, silymarin-treated control (60 and 120 mg/kg/day), diabetic, and silymarin-treated diabetic groups (60 and 120 mg/kg/day). Tissue levels of oxidative stress and biochemical parameters were measured by spectrophotometric methods. Lipid peroxidation levels in the kidney tissue were measured by fluorometric method. Insulin was determined using immunoassay. Gene expression analysis was determined by qPCR technique. The level of expression of ELMO1 and KIM1 in the diabetic groups treated with silymarin was significantly reduced (
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