ArticleScientific reports2019
Low-cost, sub-micron resolution, wide-field computational microscopy using opensource hardware.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 111 citations in OpenAlex.
- FPM2Stain Net: physics-guided super-resolution and multi-modal virtual staining for digital histopathology.Biomedical optics express · 2026Article
- LOTUS: A low-cost time-lapse automated imaging system for spatio-temporal analysis of microbial colony or biofilm development.PloS one · 2026Article
- Perspectives on label-free microscopy of heterogeneous and dynamic biological systems.Journal of biomedical optics · 2025Article
- Deciphering structural complexity of brain, joint, and muscle tissues using Fourier Ptychographic Scattered Light Microscopy.bioRxiv : the preprint server for biology · 2025Article
- VS-FPM: Large-Format, Label-Free Virtual Histopathology Microscopy.BME frontiers · 2025Article
- Microscopy image reconstruction with physics-informed denoising diffusion probabilistic model.Communications engineering · 2024Article
- Development and Assessment of Multiple Illumination Color Fourier Ptychographic Microscopy for High Throughput Sample Digitization.Sensors (Basel, Switzerland) · 2024Article
- Review
- Trackoscope: A low-cost, open, autonomous tracking microscope for long-term observations of microscale organisms.PloS one · 2024Article
- Article
- Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice.Nature methods · 2023Article
- Optical ptychography for biomedical imaging: recent progress and future directions [Invited].Biomedical optics express · 2023Review
- A review on low-cost microscopes for Open Science.Microscopy research and technique · 2022Review
- Integration of Fourier ptychography with machine learning: an alternative scheme.Biomedical optics express · 2022Article
- Automated wide-field malaria parasite infection detection using Fourier ptychography on stain-free thin-smears.Biomedical optics express · 2022Article
- Technologies for Frugal and Sensitive Point-of-Care Immunoassays.Annual review of analytical chemistry (Palo Alto, Calif.) · 2022Review
- A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences.Biochemical Society transactions · 2022Article
- Schistoscope: An Automated Microscope with Artificial Intelligence for Detection ofMicromachines · 2022Article
- Open source fraction collector/MALDI spotter for proteomics.HardwareX · 2022Article
- Picroscope: low-cost system for simultaneous longitudinal biological imaging.Communications biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The revolution in low-cost consumer photography and computation provides fertile opportunity for a disruptive reduction in the cost of biomedical imaging. Conventional approaches to low-cost microscopy are fundamentally restricted, however, to modest field of view (FOV) and/or resolution. We report a low-cost microscopy technique, implemented with a Raspberry Pi single-board computer and color camera combined with Fourier ptychography (FP), to computationally construct 25-megapixel images with sub-micron resolution. New image-construction techniques were developed to enable the use of the low-cost Bayer color sensor, to compensate for the highly aberrated re-used camera lens and to compensate for misalignments associated with the 3D-printed microscope structure. This high ratio of performance to cost is of particular interest to high-throughput microscopy applications, ranging from drug discovery and digital pathology to health screening in low-income countries. 3D models and assembly instructions of our microscope are made available for open source use.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.