Evidence map›Paper›PMID 31092855›Full record

ArticleScientific reports2019

Alterations in resting-state functional connectivity in patients with Crohn's disease in remission.

Jiancheng Hou, Rosaleena Mohanty, Veena A Nair, Keith Dodd, Poonam Beniwal-Patel, Sumona Saha, Vivek Prabhakaran

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Current approaches to studying human resting-state function in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025
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  11. Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023
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  13. Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiancheng HouDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Rosaleena MohantyDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Veena A NairDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.ORCID http://orcid.org/0000-0002-5666-3239
Keith DoddDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Poonam Beniwal-PatelDepartment of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, USA.
Sumona SahaDepartment of Medicine, Division of Gastroenterology and Hepatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA.
Vivek PrabhakaranDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, USA. vprabhakaran@uwhealth.org.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
BUILDING INTERDISCIPLINARY RESEARCH CAREER IN WOMEN'S HEALTH (BIRCWH) SCHOLARSK12HD055894 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BURNSIDE, ELIZABETH S · 2007 to 2016
$4.1M
Clinical Neuroengineering Training ProgramT32EB011434 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E., PEARCE, ROBERT A · 2011 to 2015
$869k
Stroke PlasticityK23NS086852 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PRABHAKARAN, VIVEK · 2014 to 2017
$749k
American Heart Association (American Heart Association, Inc.) T32GM008692American Heart Association (American Heart Association, Inc.) UL1TR000427NCATS NIH HHS UL1 TR000427NIBIB NIH HHS T32 EB011434NICHD NIH HHS K12 HD055894NIGMS NIH HHS T32 GM008692NINDS NIH HHS K23 NS086852U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) K12HD055894U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K23NS086852
6 · The paper itself

Abstract

Previous studies have found neural alterations in regions involved in cognitive and affective functions among Crohn's disease (CD) patients. The present work recruited 18 CD patients and 18 age-gender matched healthy controls (HC) and specifically compared differences in resting-state functional connectivity (RSFC) within the executive control network (ECN) which has been implicated in cognitive function and default mode network (DMN), which has been implicated in affective function. Additionally, we examined the correlations between RSFC in ECN and verbal fluency (VF) in both groups as well as RSFC in DMN and anxiety level in the CD group. Results showed significantly increased RSFC between the right middle frontal gyrus and right inferior parietal lobule in ECN, as well as increased RSFC between the right precuneus and right posterior cingulate cortex in DMN, among CD patients compared to HC. However, the correlations between ECN/DMN and behavioral scores in each group were not significant, which was possibility due to the limited sample size. These findings suggest that CD patients may experience changes in the connectivity patterns in ECN and DMN. Increased connectivity observed on these networks could be a potential biomarker of a neuropsychiatric manifestation of CD.

Indexed as

AdultBrainCase-Control StudiesCognitionCrohn DiseaseFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuroimagingParietal LobePrefrontal CortexRemission Induction

Identifiers

PMID31092855
PMCPMC6520362

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.