ArticleScientific reports2019
Reconstructed Skin Models Revealed Unexpected Differences in Epidermal African and Caucasian Skin.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Quantification and mitigation of system background fluorescence in fiber-optic-based imaging systems.Biomedical optics express · 2026Article
- Activation of MyD88/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin.JID innovations : skin science from molecules to population health · 2026Article
- Skin phenotype diversity across populations: from skin morphology to molecular phenotype.Frontiers in medicine · 2026Review
- Confounding Factors and Their Mitigation in Measurements of Bioelectrical Impedance at the Skin Interface.Bioengineering (Basel, Switzerland) · 2025Review
- Assessing the impact of airborne particulate pollution on human skin utilizing a novel human skin equivalent containing MUTZ-3-derived Langerhans cells.Bioengineering & translational medicine · 2025Article
- A human skin-on-a-chip platform for microneedling-driven skin cancer treatment.Materials today. Bio · 2025Article
- Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Vascularized 3D Human Skin Models in the Forefront of Dermatological Research.Advanced healthcare materials · 2024Review
- A Comparative Analysis of Biological and Synthetic Skin Models for Drug Transport Studies.Pharmaceutical research · 2023Review
- Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin types.JAAD international · 2023Article
- Review
- Evaluation of native and non-native biomaterials for engineering human skin tissue.Bioengineering & translational medicine · 2022Article
- Transcriptome Analysis Reveals Intrinsic Proinflammatory Signaling in Healthy African American Skin.The Journal of investigative dermatology · 2022Article
- Evaluation of Personalized Skincare Through in-silico Gene Interactive Networks and Cellular Responses to UVR and Oxidative Stress.Clinical, cosmetic and investigational dermatology · 2022Article
- Post-Inflammatory Hyperpigmentation in Dark Skin: Molecular Mechanism and Skincare Implications.Clinical, cosmetic and investigational dermatology · 2022Review
- A mixed community of skin microbiome representatives influences cutaneous processes more than individual members.Microbiome · 2021Article
- Risk Factors for Hospital-Acquired Pressure Injury in Surgical Critical Care Patients.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2020Article
- Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis.Biomedicines · 2020Review
- The GTEx Consortium atlas of genetic regulatory effects across human tissues.Science (New York, N.Y.) · 2020Article
- Obesity and ethnicity alter gene expression in skin.Scientific reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical observations of both normal and pathological skin have shown that there is a heterogeneity based on the skin origin type. Beside external factors, intrinsic differences in skin cells could be a central element to determine skin types. This study aimed to understand the in vitro behaviour of epidermal cells of African and Caucasian skin types in the context of 3D reconstructed skin. Full-thickness skin models were constructed with site matched human keratinocytes and papillary fibroblasts to investigate potential skin type related differences. We report that reconstructed skin epidermis exhibited remarkable differences regarding stratification and differentiation according to skin types, as demonstrated by histological appearance, gene expression analysed by DNA microarray and quantitative proteomic analysis. Signalling pathways and processes related to terminal differentiation and lipid/ceramide metabolism were up-regulated in epidermis constructed with keratinocytes from Caucasian skin type when compared to that of keratinocytes from African skin type. Specifically, the expression of proteins involved in the processing of filaggrins was found different between skin models. Overall, we show unexpected differences in epidermal morphogenesis and differentiation between keratinocytes of Caucasian and African skin types in in vitro reconstructed skin containing papillary fibroblasts that could explain the differences in ethnic related skin behaviour.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.