ArticleThe Journal of rheumatology2020
Neutrophil Extracellular Traps Profiles in Patients with Incident Systemic Lupus Erythematosus and Lupus Nephritis.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in The Journal of rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- Secondary Membranous Nephropathy. A Narrative Review.Frontiers in medicine · 2020Pooled it
- Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93).Scientific reports · 2019Trial
- Neutrophil extracellular traps and acute kidney injury: a narrative review.Frontiers in immunology · 2026Review
- Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis.Frontiers in immunology · 2026Review
- Atherosclerosis in Rheumatoid Arthritis: The Role of NETs and Management.Journal of inflammation research · 2026Review
- The role of DNASE1L3 in systemic lupus erythematosus: from pathogenesis to clinical implications.Clinical and experimental medicine · 2025Review
- Neutrophil Extracellular Traps in Systemic Lupus Erythematosus: Pathogenic Mechanisms, Crosstalk with Oxidative Stress, and Antioxidant Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells.bioRxiv : the preprint server for biology · 2025Article
- The Crosstalk Between NETs and the Complement Cascade: An Overview in Nephrological Autoimmune Disease.International journal of molecular sciences · 2025Review
- Low-density granulocytes and neutrophil extracellular trap formation are increased in incomplete systemic lupus erythematosus.Rheumatology (Oxford, England) · 2025Article
- Identification and functional characterisation of a novel DNASE1L3 variant (c.572A>G, p.Asn191Ser) in three Emirati families with systemic lupus erythematosus and hypocomplementaemic urticarial vasculitis.Lupus science & medicine · 2025Article
- Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics.Journal of nanobiotechnology · 2025Review
- Quantification of H3.1-nucleosomes using a chemiluminescent immunoassay: A reliable method for neutrophil extracellular trap detection.PloS one · 2025Article
- Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement.Arthritis research & therapy · 2024Article
- Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus.Journal of translational autoimmunity · 2024Article
- Mitochondrial Plasticity and Glucose Metabolic Alterations in Human Cancer under Oxidative Stress-From Viewpoints of Chronic Inflammation and Neutrophil Extracellular Traps (NETs).International journal of molecular sciences · 2024Review
- Early-onset lupus nephritis.Clinical kidney journal · 2024Review
- Development of a Clonal and High-Yield Mammalian Cell Line for the Manufacturing of a Hyperactive Human DNase I with Extended Plasma Half-Life Using PASylationPharmaceutics · 2024Article
- Association Between Cytokeratin 19-Specific IgG and Neutrophil Activation in Asthma.Allergy, asthma & immunology research · 2024Article
- Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.Mobile DNA · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 9 institutions in 2 countries.
Maurizio BruschiFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Alice BonanniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrea PetrettoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Augusto VaglioFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Federico PratesiFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Laura SantucciFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paola MiglioriniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Roberta BertelliFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Maricla GalettiFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Silvana BellettiFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lorenzo CavagnaFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gabriella MoroniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Franco FranceschiniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Micaela FrediFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Giulia PazzolaFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Landino AllegriFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Renato Alberto SinicoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Giampaola PesceFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Marcello BagnascoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Angelo ManfrediFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Giuseppe A RamirezFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paola RamoinoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paolo BianchiniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Francesco PuppoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Francesca PupoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Simone NegriniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Federico MattanaFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Giacomo EmmiFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Giacomo GaribottoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Domenico SantoroFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Francesco ScolariFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Angelo RavelliFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Angela TincaniFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paolo CravediFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Stefano VolpiFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Giovanni CandianoFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Gian Marco GhiggeriFrom the Laboratory of Molecular Nephrology, Core Facilities-Proteomics Laboratory, Division of Paediatric Rheumatology and Division of Nephrology, Dialysis, and Transplantation, Scientific Institute for Research and Health Care (IRCCS) Istituto Giannina Gaslini, Genoa; Nephrology Unit, University Hospital, University of Parma; Clinical Immunology Unit, Department of Internal Medicine, University of Pisa; Italian Workers' Compensation Authority (INAIL) Research Center at the University of Parma, Italy; S.Bi.Bi.T Department of the University of Parma, Parma; Division of Rheumatology, University and IRCCS Policlinico S. Matteo, Pavia; Division of Nephrology and Dialysis, IRCCS, Regina Elena, Milan; Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia; Nephrology and Dialysis, Arciospedale Santa Maria Nuova, Reggio Emilia; Department of Medicine and Surgery, University of Milan, Bicocca; Medical and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genoa; Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele, Milan; Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa; Department of Nanophysics, Italian Institute of Technology (IIT); Department of Internal Medicine, University of Genoa; Division of Nephrology, University of Genoa and Policlinico San Martino, Genoa; Lupus Clinic Department of Biomedicine, University of Florence, University Hospital Careggi, Florence; Nephrology and Dialysis Unit, University of Messina and G. Martino Hospital, Messina; Division of Nephrology and Dialysis, University of Brescia and Ospedale di Montichiari, Brescia, Italy; Nephrology Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. GMarcoGhiggeri@ospedale-gaslini.ge.it.
Istituto Giannina Gaslini · ITUniversity of Parma · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Genoa · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale Santa Maria · ITUniversity of Milan · ITUniversity of Pisa · IT
Funding
Erythropoietin mediated immunoregulation in murine lupus nephritisR01AI132949 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRAVEDI, PAOLO · 2018 to 2022
$2.1MErythropoietin and trained immunity intransplantationR56AI132949 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRAVEDI, PAOLO · 2024 to 2024
$456kNIAID NIH HHS R01 AI132949NIAID NIH HHS R56 AI132949
Abstract
objectiveNeutrophil extracellular traps (NET) expose modified antigens for autoantibodies in vasculitis. Little is known about levels and removal pathways of NET in systemic lupus erythematosus (SLE), especially in lupus nephritis (LN). We determined circulating levels and defined NET removal in large subsets of patients with incident SLE (iSLE), some of whom had new-onset nephritis.
methodsSerum levels of NET (ELISA), DNase1/DNase1L3 (ELISA), and DNase activity (functional assay) were determined in 216 patients with iSLE [103 had incident LN (iLN)], in 50 patients with other primary glomerulonephritis, and in healthy controls.
resultsSerum NET levels were very high in iSLE/iLN compared to all groups of controls and correlated with anti-dsDNA, C3-C4, and proteinuria; iLN had the highest levels. DNase activity was decreased in iLN compared to SLE (20% had one-half DNase activity) despite similar serum levels of DNase1/DNase1L3. In these cases, pretreatment of serum with protein A restored DNase efficiency; 1 patient was homozygous for a c.289_290delAC variant of
conclusionPatients with iLN have increased circulating NET and reduced DNase activity, the latter being explained by the presence of inhibitory substances in circulation and/or by rare
Indexed as
Severity of Illness IndexAdolescentAdultAutoantibodiesChildComorbidityDeoxyribonuclease IDNAEndodeoxyribonucleasesEnzyme-Linked Immunosorbent AssayExtracellular TrapsFemaleHumansIncidenceLupus Erythematosus, SystemicLupus NephritisAutoantibodiesDeoxyribonuclease IDNADNASE1L3 protein, humanDNASE1 protein, humanEndodeoxyribonucleasesDNASE ACTIVITYDNASE LEVELDNASE MUTATIONSNEUTROPHIL EXTRACELLULAR TRAPS
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