ArticleArchives of disease in childhood. Fetal and neonatal edition2020
Effect of spontaneous breathing on umbilical venous blood flow and placental transfusion during delayed cord clamping in preterm lambs.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Ventilatory Assistance Before Umbilical Cord Clamping in Extremely Preterm Infants: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Deferred cord clamping in twin pregnancies: benefit, risk, or missed opportunity? A narrative review.Resuscitation plus · 2026Review
- Impact of cord clamping on haemodynamic transition in term newborn infants.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Physiological-Based Cord Clamping: When the Baby Is Ready for Clamping.Neonatology · 2024Review
- Adverse respiratory patterns in near-term spontaneously breathing newborn lambs with elevated airway liquid volumes at birth.Frontiers in pediatrics · 2024Article
- Increased risk of bradycardia in vigorous infants receiving early as compared to delayed cord clamping at birth.Journal of perinatology : official journal of the California Perinatal Association · 2023Observational
- Differential Alveolar and Systemic Oxygenation during Preterm Resuscitation with 100% Oxygen during Delayed Cord Clamping.American journal of perinatology · 2023Article
- Cardiac Asystole at Birth Re-Visited: Effects of Acute Hypovolemic Shock.Children (Basel, Switzerland) · 2023Review
- Respiratory patterns in spontaneously breathing near-term lambs delivered by caesarean section under spinal anaesthesia.Frontiers in pediatrics · 2023Article
- Assessing lung aeration using ultrasound after birth in near-term lambs at risk of respiratory distress.Frontiers in pediatrics · 2023Article
- Making the Argument for Intact Cord Resuscitation: A Case Report and Discussion.Children (Basel, Switzerland) · 2022Review
- Effect of breathing on venous return during delayed cord clamping: an observational study.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Effects of spontaneous first breath on placental transfusion in term neonates born by cesarean section: A randomized controlled trial.Frontiers in pediatrics · 2022Article
- Sustained Inflation Reduces Pulmonary Blood Flow during Resuscitation with an Intact Cord.Children (Basel, Switzerland) · 2021Article
- Changes in Umbilico-Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model.Children (Basel, Switzerland) · 2021Article
- High-CPAP Does Not Impede Cardiovascular Changes at Birth in Preterm Sheep.Frontiers in pediatrics · 2020Article
- Placental Transfusion for Asphyxiated Infants.Frontiers in pediatrics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuring delayed umbilical cord clamping, the factors underpinning placental transfusion remain unknown. We hypothesised that reductions in thoracic pressure during inspiration would enhance placental transfusion in spontaneously breathing preterm lambs.
objectiveInvestigate the effect of spontaneous breathing on umbilical venous flow and body weight in preterm lambs.
methodsPregnant sheep were instrumented at 132-133 days gestational age to measure fetal common umbilical venous, pulmonary and cerebral blood flows as well as arterial and intrapleural (IP) pressures. At delivery, doxapram and caffeine were administered to promote breathing. Lamb body weights were measured continuously and breathing was assessed by IP pressure changes.
resultsIn 6 lambs, 491 out of 1117 breaths were analysed for change in body weight. Weight increased in 46.6% and decreased in 47.5% of breaths. An overall mean increase of 0.02±2.5 g per breath was calculated, and no net placental transfusion was observed prior to cord clamping (median difference in body weight 52.3 [-54.9-166.1] g, p=0.418). Umbilical venous (UV) flow transiently decreased with each inspiration, and in some cases ceased, before UV flow normalised during expiration. The reduction in UV flow was positively correlated with the standardised reduction in (IP) pressure, increasing by 109 mL/min for every SD reduction in IP pressure. Thus, the reduction in UV flow was closely related to inspiratory depth.
conclusionsSpontaneous breathing had no net effect on body weight in preterm lambs at birth. UV blood flow decreased as inspiratory effort increased, possibly due to constriction of the inferior vena cava caused by diaphragmatic contraction, as previously observed in human fetuses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.