Evidence map›Paper›PMID 31092628›Full record

ArticleOccupational and environmental medicine2019

Relationship between early prescription dispensing patterns and work disability in a cohort of low back pain workers' compensation claimants: a historical cohort study.

Nancy Carnide, Sheilah Hogg-Johnson, Mieke Koehoorn, Andrea D Furlan, Pierre Côté

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nancy CarnideInstitute for Work and Health, Toronto, Ontario, Canada.ORCID 0000-0001-7892-5626
Sheilah Hogg-JohnsonInstitute for Work and Health, Toronto, Ontario, Canada.
Mieke KoehoornInstitute for Work and Health, Toronto, Ontario, Canada.
Andrea D FurlanInstitute for Work and Health, Toronto, Ontario, Canada.
Pierre CôtéCanadian Memorial Chiropractic College, Toronto, Ontario, Canada.
Canadian Memorial Chiropractic College · CAInstitute for Work & Health · CAUniversity Health Network · CAUniversity of British Columbia · CA

Funding

CIHR 115032
6 · The paper itself

Abstract

objectivesTo examine and compare whether dispensing of prescription opioids, non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs) within 8 weeks after a work-related low back pain (LBP) injury is associated with work disability.

methodsA historical cohort study of 55 571 workers' compensation claimants with LBP claims in British Columbia from 1998 to 2009 was conducted using linked compensation, dispensing and healthcare data. Four exposures were constructed to estimate the effect on receipt of benefits and days on benefits 1 year after injury: drug class(es) dispensed, days' supply, strength of opioids dispensed and average daily morphine-equivalent dose.

resultsCompared with claimants receiving NSAIDs and/or SMRs, the incidence rate ratio (IRR) of days on benefits was 1.09 (95% CI 1.04 to 1.14) for claimants dispensed opioids only and 1.26 (95% CI 1.22 to 1.30) for claimants dispensed opioids with NSAIDs and/or SMRs. Compared with weak opioids only, the IRR for claimants dispensed strong opioids only or strong and weak opioids combined was 1.21 (95% CI 1.12 to 1.30) and 1.29 (95% CI 1.20 to 1.39), respectively. The incident rate of days on benefits associated with each 7-day increase in days supplied of opioids, NSAIDs and SMRs was 10%, 4% and 3%, respectively. Similar results were seen for receipt of benefits, though effect sizes were larger.

conclusionsFindings suggest provision of early opioids leads to prolonged work disability compared with NSAIDs and SMRs, though longer supplies of all drug classes are also associated with work disability. Residual confounding likely partially explains the findings. Research is needed that accounts for prescriber, system and workplace factors.

Indexed as

Workers' CompensationAdultAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalBack InjuriesBritish ColumbiaCohort StudiesDrug PrescriptionsFemaleHumansLow Back PainMaleMiddle AgedNeuromuscular AgentsOccupational InjuriesTime FactorsAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalNeuromuscular Agentsadministrative datacohort studylow back painopioidsprescription dispensingwork disabilityworkers’ compensation

Identifiers

PMID31092628
PMCPMC6703123
OpenAlexW2946385626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.