Evidence map›Paper›PMID 31092621›Full record

ArticleNeurology2019

Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury.

Kevin Vallotton, Eveline Huber, Reto Sutter, Armin Curt, Markus Hupp, Patrick Freund

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  14. The influence of conventional TThe journal of spinal cord medicine · 2023
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  19. Longitudinal changes of spinal cord grey and white matter following spinal cord injury.Journal of neurology, neurosurgery, and psychiatry · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kevin VallottonFrom the Spinal Cord Injury Center (K.V., E.H., A.C., M.H., P.F.) and Department of Radiology (R.S.), Balgrist University Hospital; University of Zurich (K.V., E.H., A.C., M.H., P.F., R.S.), Switzerland; Wellcome Trust Centre for Neuroimaging (P.F.) and Department of Brain Repair and Rehabilitation (P.F.), UCL Institute of Neurology, University College London, UK; and Department of Neurophysics (P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Eveline HuberFrom the Spinal Cord Injury Center (K.V., E.H., A.C., M.H., P.F.) and Department of Radiology (R.S.), Balgrist University Hospital; University of Zurich (K.V., E.H., A.C., M.H., P.F., R.S.), Switzerland; Wellcome Trust Centre for Neuroimaging (P.F.) and Department of Brain Repair and Rehabilitation (P.F.), UCL Institute of Neurology, University College London, UK; and Department of Neurophysics (P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Reto SutterFrom the Spinal Cord Injury Center (K.V., E.H., A.C., M.H., P.F.) and Department of Radiology (R.S.), Balgrist University Hospital; University of Zurich (K.V., E.H., A.C., M.H., P.F., R.S.), Switzerland; Wellcome Trust Centre for Neuroimaging (P.F.) and Department of Brain Repair and Rehabilitation (P.F.), UCL Institute of Neurology, University College London, UK; and Department of Neurophysics (P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Armin CurtFrom the Spinal Cord Injury Center (K.V., E.H., A.C., M.H., P.F.) and Department of Radiology (R.S.), Balgrist University Hospital; University of Zurich (K.V., E.H., A.C., M.H., P.F., R.S.), Switzerland; Wellcome Trust Centre for Neuroimaging (P.F.) and Department of Brain Repair and Rehabilitation (P.F.), UCL Institute of Neurology, University College London, UK; and Department of Neurophysics (P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Markus HuppFrom the Spinal Cord Injury Center (K.V., E.H., A.C., M.H., P.F.) and Department of Radiology (R.S.), Balgrist University Hospital; University of Zurich (K.V., E.H., A.C., M.H., P.F., R.S.), Switzerland; Wellcome Trust Centre for Neuroimaging (P.F.) and Department of Brain Repair and Rehabilitation (P.F.), UCL Institute of Neurology, University College London, UK; and Department of Neurophysics (P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Patrick FreundFrom the Spinal Cord Injury Center (K.V., E.H., A.C., M.H., P.F.) and Department of Radiology (R.S.), Balgrist University Hospital; University of Zurich (K.V., E.H., A.C., M.H., P.F., R.S.), Switzerland; Wellcome Trust Centre for Neuroimaging (P.F.) and Department of Brain Repair and Rehabilitation (P.F.), UCL Institute of Neurology, University College London, UK; and Department of Neurophysics (P.F.), Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Patrick.Freund@Balgrist.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess whether preserved dorsal and ventral midsagittal tissue bridges after traumatic cervical spinal cord injury (SCI) encode tract-specific electrophysiologic properties and are predictive of appropriate recovery.

methodsIn this longitudinal study, we retrospectively assessed MRI scans at 1 month after SCI that provided data on width and location (dorsal vs ventral) of midsagittal tissue bridges in 28 tetraplegic patients. Regression analysis assessed associations between midsagittal tissue bridges and motor- and sensory-specific electrophysiologic recordings and appropriate outcome measures at 12 months after SCI.

resultsGreater width of dorsal midsagittal tissue bridges at 1 month after SCI identified patients who were classified as being sensory incomplete at 12 months after SCI (

conclusionMidsagittal tissue bridges, detectable early after SCI, underwrite tract-specific electrophysiologic communication and are predictors of appropriate sensorimotor recovery. Neuroimaging biomarkers of midsagittal tissue bridges may be integrated into the diagnostic workup, prediction of recovery, and patients' stratification in clinical trials.

Indexed as

Recovery of FunctionAdultAgedCervical CordCervical VertebraeEvoked Potentials, MotorEvoked Potentials, SomatosensoryFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeck InjuriesPrognosisQuadriplegia

Identifiers

PMID31092621
PMCPMC6598793

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.