Evidence map›Paper›PMID 31092599›Full record

ArticleThe Journal of biological chemistry2019

Murine epithelial sodium (Na

Xue-Ping Wang, Seohyun Janice Im, Deidra M Balchak, Nicolas Montalbetti, Marcelo D Carattino, Evan C Ray, Ossama B Kashlan

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Epithelial NaComprehensive Physiology · 2024
    Review
  5. Review
  6. Review
  7. Bile acids regulate the epithelial NaThe Journal of physiology · 2022
    Article
  8. Bile acids and salt-sensitive hypertension: a role of the gut-liver axis.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  9. Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  10. Article
  11. Downregulation of CaFrontiers in pharmacology · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Xue-Ping WangFrom the Renal-Electrolyte Division, Department of Medicine.
Seohyun Janice ImFrom the Renal-Electrolyte Division, Department of Medicine.
Deidra M BalchakFrom the Renal-Electrolyte Division, Department of Medicine.
Nicolas MontalbettiFrom the Renal-Electrolyte Division, Department of Medicine.
Marcelo D CarattinoFrom the Renal-Electrolyte Division, Department of Medicine.
Evan C RayFrom the Renal-Electrolyte Division, Department of Medicine.
Ossama B KashlanFrom the Renal-Electrolyte Division, Department of Medicine, obk2@pitt.edu.ORCID 0000-0003-0537-6720
Renal Association · GBUniversity of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
ENaC regulation by biliary factorsR01DK125439 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2020 to 2023
$1.8M
Allosteric ENaC RegulationR01DK098204 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2014 to 2018
$1.7M
Proteolytic activation of ENaC in Proteinuric Kidney DiseaseK08DK110332 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, EVAN CROSS · 2016 to 2021
$903k
NIDDK NIH HHS K08 DK110332NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK098204NIDDK NIH HHS R01 DK125439
6 · The paper itself

Abstract

The epithelial sodium channel (ENaC) mediates Na

Indexed as

AnimalsAntioxidantsBile Acids and SaltsBilirubinCholagogues and CholereticsDeoxycholic AcidEpithelial Sodium ChannelsGastrointestinal AgentsGene Expression RegulationHumansIon TransportLipoylationMiceOocytesProteolysisSodiumAntioxidantsBile Acids and SaltsBilirubinCholagogues and CholereticsDeoxycholic AcidEpithelial Sodium ChannelsGastrointestinal AgentsSodiumallosteric regulationbile acidbililrubincholic aciddegenerin familyepithelial sodium channel (ENaC)kidney tubulephysico-chemical propertiesprotein palmitoylationproteolysisrenal physiologytrimeric cation channel

Identifiers

PMID31092599
PMCPMC6664190
OpenAlexW2945781641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.