Evidence map›Paper›PMID 31092540›Full record

ArticleGenetics2019

The Paf1 Complex Broadly Impacts the Transcriptome of

Mitchell A Ellison, Alex R Lederer, Marcie H Warner, Travis N Mavrich, Elizabeth A Raupach, Lawrence E Heisler, Corey Nislow, Miler T Lee, Karen M Arndt

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. RNA Pol II Assembly Affects ncRNA Expression.International journal of molecular sciences · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mitchell A EllisonDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.ORCID 0000-0002-5682-096X
Alex R LedererDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.ORCID 0000-0001-6381-5088
Marcie H WarnerDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
Travis N MavrichDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
Elizabeth A RaupachDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
Lawrence E HeislerTerrance Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Ontario M5S 3E1, Canada.
Corey NislowDepartment of Pharmaceutical Sciences, University of British Columbia, Vancouver BC V6T 1Z3, British Columbia, Canada.
Miler T LeeDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.ORCID 0000-0003-0933-0551
Karen M ArndtDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania 15260 arndt@pitt.edu.ORCID 0000-0003-1320-9957
University of Pittsburgh · USUniversity of British Columbia · CAUniversity of Toronto · CA

Funding

TRANSCRIPTION FACTOR MUTANTS OF YEASTR01GM052593 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARNDT, KAREN M · 1995 to 2020
$7.9M
Understanding the recruitment of a key epigenetic regulatorF31GM129917 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ELLISON, MITCHELL A · 2018 to 2019
$90k
NIGMS NIH HHS F31 GM129917NIGMS NIH HHS R01 GM052593
6 · The paper itself

Abstract

The Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investigated the extent to which the functions of Paf1C combine to regulate the

Indexed as

Gene Expression Regulation, FungalTranscriptomeChromatinCopper Transport ProteinsHistonesIron-Binding ProteinsNuclear ProteinsProtein Processing, Post-TranslationalRNA, UntranslatedSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsChromatinCopper Transport ProteinsFET4 protein, S cerevisiaeHistonesIron-Binding ProteinsNuclear ProteinsPAF1 protein, S cerevisiaeRNA, UntranslatedSaccharomyces cerevisiae Proteinschromatinhistone modificationsnoncoding RNAPaf1 complexRNA polymerase II

Identifiers

PMID31092540
PMCPMC6614894
OpenAlexW2918715573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.