Evidence map›Paper›PMID 31092335›Full record

ArticleBiochemical and biophysical research communications2019

NLRP3 inhibition improves heart function in GPER knockout mice.

Hao Wang, Xuming Sun, Hunter S Hodge, Carlos M Ferrario, Leanne Groban

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. The Role of Inflammasomes in Heart Failure.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases.Molecules (Basel, Switzerland) · 2021
    Review
  14. Female Heart Health: Is GPER the Missing Link?Frontiers in endocrinology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hao WangDepartment of Anesthesiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157-1009, USA; Department of Internal Medicine-Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157, USA. Electronic address: haowang@wakehealth.edu.
Xuming SunDepartment of Anesthesiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157-1009, USA. Electronic address: xsun@wakehealth.edu.
Hunter S HodgeDepartment of Anesthesiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157-1009, USA. Electronic address: hshodge@wakehealth.edu.
Carlos M FerrarioDepartment of Surgery, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157, USA; Division of Public Health Sciences, Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157, USA. Electronic address: cferrari@wakehealth.edu.
Leanne GrobanDepartment of Anesthesiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157-1009, USA; Department of Internal Medicine-Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC, 27157, USA. Electronic address: lgroban@wakehealth.edu.
Wake Forest University · US

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 1994 to 2019
$34.8M
Interplay Between Estrogen, GPR30 and Chymase/RAS in Diastolic FunctionR01AG033727 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 2009 to 2017
$2.8M
NHLBI NIH HHS P01 HL051952NIA NIH HHS R01 AG033727
6 · The paper itself

Abstract

The molecular mechanisms of postmenopausal heart diseases in women may involve the loss of estrogen-deactivation of its membrane receptor, G-protein coupled estrogen receptor (GPER), and subsequent activation of the cardiac NLRP3 inflammasome, a component of the innate immune system. To study the potential effects of cardiac GPER on NLRP3-mediated inflammatory pathways, we characterized changes in innate immunity gene transcripts in hearts from 6-month-old cardiomyocyte-specific GPER knockout (KO) mice and their GPER-intact wild type (WT) littermates using RT

Indexed as

AnimalsFemaleFuransGene DeletionHeartHeterocyclic Compounds, 4 or More RingsIndenesMaleMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, EstrogenReceptors, G-Protein-CoupledSulfonamidesSulfonesUp-RegulationFuransGPER1 protein, mouseHeterocyclic Compounds, 4 or More RingsIndenesN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptors, EstrogenReceptors, G-Protein-CoupledSulfonamidesSulfonesGPERHeart failureInflammationNLRP3

Identifiers

PMID31092335
PMCPMC6545146
OpenAlexW2943960056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.