Evidence map›Paper›PMID 31092283›Full record

ArticleParasites & vectors2019

Delivery of SA35 and SA40 peptides in mice enhances humoral and cellular immune responses and confers protection against Cryptosporidium parvum infection.

Fabio Tosini, Alessandra Ludovisi, Daniele Tonanzi, Marco Amati, Simona Cherchi, Edoardo Pozio, Maria Angeles Gómez-Morales

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Exploring the repertoire of rhomboid proteases inFrontiers in cellular and infection microbiology · 2026
    Article
  2. UnveilingFrontiers in cellular and infection microbiology · 2024
    Article
  3. Article
  4. Bioactive Peptides against Human Apicomplexan Parasites.Antibiotics (Basel, Switzerland) · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fabio TosiniEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy. fabio.tosini@iss.it.
Alessandra LudovisiEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy.
Daniele TonanziEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy.
Marco AmatiEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy.
Simona CherchiEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy.
Edoardo PozioEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy.
Maria Angeles Gómez-MoralesEuropean Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy. mariaangeles.gomezmorales@iss.it.
Istituto Superiore di Sanità · IT

Funding

European Commission SANCO/2006/FOOD SAFETY/032
6 · The paper itself

Abstract

backgroundCryptosporidium parvum is a major cause of diarrhea in children and ruminants at the earliest stages of life. Maternal antibodies represent the main shield of neonate mammals for most of the infections. Two recombinant antigens (SA35 and SA40), portions of two C. parvum proteins, were tested for their ability to induce immune responses in adult mice and for protection on neonate BALB/c mice born from females immunised by mucosal delivery of both peptides.

methodsAdult BALB/c mice were intraperitoneally immunised with SA35 and SA40, separately or mixed, and their immune response was characterised. Furthermore, BALB/c pregnant mice were immunised by mucosal delivery with an SA35/40 mix, before and during pregnancy. Soon after birth, their offspring were infected with two doses (1 × 10

resultsIntraperitoneal immunisation with SA35 and SA40 induced specific IgG and IgG1 in serum, specific IgA in the intestinal mucosa, increase of CD3+/CD4+ and CD30+ cells in splenocytes, which produced IFN-γ. Neonates born from immunised mice and infected with 1 × 10

conclusionsSA35 and SA40 peptides induce specific humoral and cell-mediated immune responses to C. parvum in adult mice. Moreover, mucosal administration of the SA35/40 mix in pregnant mice reduces C. parvum burden in their litters.

Indexed as

Immunity, CellularImmunity, HumoralAnimalsAnimals, NewbornAntibodies, ProtozoanAntigens, ProtozoanCryptosporidiosisCryptosporidium parvumFemaleImmunity, Maternally-AcquiredImmunizationImmunoglobulin AImmunoglobulin GIntestinal MucosaMiceMice, Inbred BALB CAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin AImmunoglobulin GPeptidesProtozoan ProteinsProtozoan VaccinesCpa135Cryptosporidiumgp900Maternal transferMucosal immunisationRecombinant antigen

Identifiers

PMID31092283
PMCPMC6518611
OpenAlexW2947025010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.