Letter by Khan et al Regarding Article, "Artificially Sweetened Beverages and Stroke, Coronary Heart Disease, and All-Cause Mortality in the Women's Health Initiative".

Tauseef A Khan, Vasanti S Malik, John L Sievenpiper

Registry-linked trialAbstract readLetterComment

In one paragraph

Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04245826 (Changing or Substituting Low-calorie Sweetened Beverages for Sugar-Sweetened Beverages or Water and Cardiometabolic Outcomes), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04245826 unknown statusnot on this map

Changing or Substituting Low-calorie Sweetened Beverages for Sugar-Sweetened Beverages or Water and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies

TypeobservationalSponsorUniversity of TorontoRan2019 to 2020Enrolled1ConditionsAdiposity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular DiseasesArmsChange in LCSBs Intake, Substitute LCSBs for SSBs or Water

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Prospective Cohort Studies.Diabetes care · 2022
Pooled it
Dietary Guidance, Sensory, Health and Safety Considerations When Choosing Low and No-Calorie Sweeteners.Nutrients · 2025
Review
WHO guideline on the use of non-sugar sweeteners: a need for reconsideration.European journal of clinical nutrition · 2023
Review
Rationale, Design and Participants Baseline Characteristics of a Crossover Randomized Controlled Trial of the Effect of Replacing SSBs with NSBs versus Water on Glucose Tolerance, Gut Microbiome and Cardiometabolic Risk in Overweight or Obese Adult SSB Consumer: Strategies to Oppose SUGARS with Non-Nutritive Sweeteners or Water (STOP Sugars NOW) Trial and Ectopic Fat Sub-Study.Nutrients · 2023
Article

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Tauseef A KhanDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, Canada.

Vasanti S MalikDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

John L SievenpiperDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Coronary DiseaseStrokeBeveragesFemaleHumansSweetening AgentsWomen's HealthSweetening Agents

Identifiers

PMID31092156

DOI10.1161/STROKEAHA.119.025571

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

NCT04245826ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.