Evidence map›Paper›PMID 31092010›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2019

Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus.

Baohai Shao, Leila R Zelnick, Jake Wimberger, Jonathan Himmelfarb, John Brunzell, W Sean Davidson, Janet K Snell-Bergeon, Karin E Bornfeldt, Ian H de Boer, Jay W Heinecke

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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  15. HDL and ASCVD.Advances in experimental medicine and biology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Baohai ShaoFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
Leila R ZelnickFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
Jake WimbergerFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
Jonathan HimmelfarbFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
John BrunzellFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
W Sean DavidsonDepartment of Pathology and Laboratory Medicine, University of Cincinnati, OH (W.S.D.).
Janet K Snell-BergeonBarbara Davis Center for Diabetes, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora (J.K.S.-B.).
Karin E BornfeldtFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
Ian H de BoerFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
Jay W HeineckeFrom the Department of Medicine, University of Washington, Seattle (B.S., L.R.Z., J.W., J.H., J.B., K.E.B., I.H.d.B., J.W.H.).
University of Washington · USUniversity of Cincinnati · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Project 3 - HDL Structure/Function in LCAT Deficient HumansP01HL128203 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tomas Vaisar · 2016 to 2026
$25.1M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI VAISAR, TOMAS · 2008 to 2019
$23.5M
Quantitative Assessment of HDL FunctionR01HL112625 · NHLBI · UNIVERSITY OF WASHINGTON · PI HEINECKE, JAY W · 2012 to 2016
$2.1M
Cardioprotective Mechanisms of HDLR01HL108897 · NHLBI · UNIVERSITY OF WASHINGTON · PI HEINECKE, JAY W · 2012 to 2015
$1.7M
APOC3, HDL Function and Cardiovascular Complications of T1DMDP3DK108209 · NIDDK · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E., HEINECKE, JAY W · 2015 to 2015
$1.6M
Anti-inflammatory properties of high-density lipoproteinR00HL091055 · NHLBI · UNIVERSITY OF WASHINGTON · PI SHAO, BAOHAI · 2010 to 2012
$747k
NHLBI NIH HHS P01 HL092969NHLBI NIH HHS P01 HL128203NHLBI NIH HHS R00 HL091055NHLBI NIH HHS R01 HL108897NHLBI NIH HHS R01 HL112625NIDDK NIH HHS DP3 DK108209NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

Objective- Albuminuria is an important risk factor for cardiovascular disease in diabetes mellitus. We determined whether albuminuria associates with alterations in the proteome of HDL (high-density lipoprotein) of subjects with type 1 diabetes mellitus and whether those alterations associated with coronary artery calcification. Approach and Results- In a cross-sectional study of 191 subjects enrolled in the DCCT (Diabetes Control and Complications Trial)/EDIC study (Epidemiology of Diabetes Interventions and Complications), we used isotope dilution tandem mass spectrometry to quantify 46 proteins in HDL. Stringent statistical analysis demonstrated that 8 proteins associated with albuminuria. Two of those proteins, AMBP (α1-microglobulin/bikunin precursor) and PTGDS (prostaglandin-H2 D-isomerase), strongly and positively associated with the albumin excretion rate ( P<10

Indexed as

ProteomicsAdultAlbuminuriaAryldialkylphosphataseCoronary Artery DiseaseCross-Sectional StudiesDiabetes Mellitus, Type 1FemaleGlomerular Filtration RateHumansLipoproteins, HDLMaleMiddle AgedVascular CalcificationAryldialkylphosphataseLipoproteins, HDLPON1 protein, humanPON3 protein, humanalbuminuriaatherosclerosiskidney diseaseslipoproteinsproteomicstriglycerides

Identifiers

PMID31092010
PMCPMC6594860
OpenAlexW2946063083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.