Trial reportNutrients2019
Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men.
Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- The Role of Peptides in Nutrition: Insights into Metabolic, Musculoskeletal, and Behavioral Health: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults.Journal of cachexia, sarcopenia and muscle · 2022Pooled it
- The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review.Amino acids · 2021Pooled it
- The effects of collagen peptide supplementation on appetite and post-exercise energy intake in females: a randomised controlled trial.The British journal of nutrition · 2025Trial
- Comparing the Effects of Collagen Hydrolysate and Dairy Protein on Recovery from Eccentric Exercise: A Double Blind, Placebo-Controlled Study.Nutrients · 2024Trial
- A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men.Clinical nutrition (Edinburgh, Scotland) · 2021Trial
- The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training.Nature communications · 2021Trial
- The Impact of Body Resistance Training Exercise on Biomedical Profile at High Altitude: A Randomized Controlled Trial.BioMed research international · 2021Trial
- Casein Ingestion Does Not Increase Muscle Connective Tissue Protein Synthesis Rates.Medicine and science in sports and exercise · 2020Trial
- Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men.Journal of sports science & medicine · 2019Trial
- Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.Translational sports medicine · 2026Review
- Specific collagen peptides supplementation increases collagen type I content in skeletal muscle after 12 weeks of high-load resistance training: a randomized controlled trial.Frontiers in physiology · 2026Article
- A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo.npj aging · 2025Article
- Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo.Developmental neurobiology · 2025Article
- Comment on 'Systematic Review and Meta-Analysis of Protein Intake to Support Muscle Mass and Function in Healthy Adults' by Nunes et al.-The Authors' Reply.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Fish Collagen Supplementation and Proteomic Features in Healthy Women-A Crossover Study.Nutrients · 2025Article
- Comment on "Systematic Review and Meta-Analysis of Protein Intake to Support Muscle Mass and Function in Healthy Adults" by Nunes et al.Journal of cachexia, sarcopenia and muscle · 2025Article
- Effects of 24 weeks of collagen supplementation in active adults: Impact on body composition, neuromuscular and cardiorespiratory fitness.Biology of sport · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Evidence has shown that protein supplementation following resistance exercise training (RET) helps to further enhance muscle mass and strength. Studies have demonstrated that collagen peptides containing mostly non-essential amino acids increase fat-free mass (FFM) and strength in sarcopenic men. The aim of this study was to investigate whether collagen peptide supplementation in combination with RET influences the protein composition of skeletal muscle. Twenty-five young men (age: 24.2 ± 2.6 years, body mass (BM): 79.6 ± 5.6 kg, height: 185.0 ± 5.0 cm, fat mass (FM): 11.5% ± 3.4%) completed body composition and strength measurements and vastus lateralis biopsies were taken before and after a 12-week training intervention. In a double-blind, randomized design, subjects consumed either 15 g of specific collagen peptides (COL) or a non-caloric placebo (PLA) every day within 60 min after their training session. A full-body hypertrophy workout was completed three times per week and included four exercises using barbells. Muscle proteome analysis was performed by liquid chromatography tandem mass spectrometry (LC-MS/MS). BM and FFM increased significantly in COL compared with PLA, whereas no differences in FM were detected between the two groups. Both groups improved in strength levels, with a slightly higher increase in COL compared with PLA. In COL, 221 higher abundant proteins were identified. In contrast, only 44 proteins were of higher abundance in PLA. In contrast to PLA, the upregulated proteins in COL were mostly associated with the protein metabolism of the contractile fibers. In conclusion, the use of RET in combination with collagen peptide supplementation results in a more pronounced increase in BM, FFM, and muscle strength than RET alone. More proteins were upregulated in the COL intervention most of which were associated with contractile fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.