ArticleCell reports2019
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
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Who cites it
45 citing papers in PubMed, 61 citations in OpenAlex.
- PIP4K2A depletion suppresses AKT signaling and enhances chemotherapy sensitivity in T-cell lymphoblastic lymphoma cells.Biochemical and biophysical research communications · 2026Article
- From lipid dynamics to precision predictions: A new approach methodology for precision modeling of phosphoinositide signaling.Journal of precision medicine (Amsterdam, Netherlands) · 2026Article
- PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.Translational stroke research · 2026Article
- Article
- A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.The Journal of biological chemistry · 2026Article
- Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Review
- Application of chemical similarity and bioisosteres to find allosteric inhibitors of type 2 lipid kinase γ.Scientific reports · 2025Article
- PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.bioRxiv : the preprint server for biology · 2025Article
- PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer.Cell reports · 2025Article
- PI5P4K inhibitors: promising opportunities and challenges.The FEBS journal · 2025Review
- Polygenic risk scores of fasting insulin and insulin-related traits in a Taiwanese Han population.Cell & bioscience · 2025Article
- PI(4,5)PBiochimica et biophysica acta. Molecular and cell biology of lipids · 2025Review
- Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities.Nature reviews. Cancer · 2025Review
- Deciphering the Population Characteristics of Leiqiong Cattle Using Whole-Genome Sequencing Data.Animals : an open access journal from MDPI · 2025Article
- PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability.Cancer research · 2025Article
- Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis.Cardiovascular therapeutics · 2025Article
- Exploring the Potential Role of Oligodendrocyte-Associated PIP4K2A in Alzheimer's Disease Complicated with Type 2 Diabetes Mellitus via Multi-Omic Analysis.International journal of molecular sciences · 2024Article
- Nonlinear dynamics in phosphoinositide metabolism.Current opinion in cell biology · 2024Review
- Cancer Cells Hijack Physiologic Metabolic Signals to Seed Liver Metastasis.Cancer research · 2024Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Diana G WangMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Weill Cornell Medicine/Rockefeller University/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY 10021, USA.
Marcia N PaddockMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Hematology and Oncology Division, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Mark R LundquistMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Janet Y SunMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Oksana MashadovaMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Solomon AmadiumeMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Timothy W BumpusDepartment of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Cindy HodakoskiMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Benjamin D HopkinsMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Matthew FineMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Amanda HillMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
T Jonathan YangMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Jeremy M BaskinDepartment of Chemistry and Chemical Biology and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
Lukas E DowMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Hematology and Oncology Division, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10021, USA.
Lewis C CantleyMeyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: lcantley@med.cornell.edu.
Weill Cornell Medicine · USCornell University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MRole of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2MProject 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI SCHAFFER, CHRIS B · 2016 to 2020
$10.2MMechanisms controlling phosphoinositide synthesis at the plasma membraneR00GM110121 · NIGMS · CORNELL UNIVERSITY · PI BASKIN, JEREMY · 2015 to 2017
$747kCell SorterS10OD019986 · OD · HOSPITAL FOR SPECIAL SURGERY · PI LU, THERESA T. · 2015 to 2015
$600kDefining the genetic requirements for maintenance of colorectal cancerK22CA181280 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DOW, LUKAS EDWARD · 2014 to 2016
$584kNCI NIH HHS K22 CA181280NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA197588NCI NIH HHS U54 CA210184NIGMS NIH HHS R00 GM110121NIGMS NIH HHS T32 GM007739NIH HHS S10 OD019986
Abstract
Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P
Indexed as
Signal TransductionAnimalsHumansInsulinPhosphatidylinositol 4,5-DiphosphatePhosphotransferases (Alcohol Group Acceptor)InsulinPhosphatidylinositol 4,5-DiphosphatePhosphotransferases (Alcohol Group Acceptor)PIP4K2A protein, humanPIP4K2C protein, humanAktinsulinPI(3,4,5)P(3)PI3KPI(4,5)P(2)PI5P4KPIP4KPIP5KRTKsignaling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.