Evidence map›Paper›PMID 31091436›Full record

ArticleCell reports2019

Genetic and Functional Dissection of the Role of Individual 5-HT

Benedetta Assetta, Jenna Morris-Love, Gretchen V Gee, Abigail L Atkinson, Bethany A O'Hara, Melissa S Maginnis, Sheila A Haley, Walter J Atwood

Abstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benedetta AssettaDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Jenna Morris-LoveDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA; Graduate Program in Pathobiology, Brown University, Providence, RI, USA.
Gretchen V GeeDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Abigail L AtkinsonDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Bethany A O'HaraDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Melissa S MaginnisDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Sheila A HaleyDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA.
Walter J AtwoodDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA. Electronic address: walter_atwood@brown.edu.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
SYNTHETIC CHEMISTRY COREP01NS065719 · NINDS · BROWN UNIVERSITY · PI GEE, GRETCHEN VOGEL · 2009 to 2018
$12.3M
Virus-Host Cell Interactions in AIDS-Associated PMLR01NS043097 · NINDS · BROWN UNIVERSITY · PI ATWOOD, WALTER J · 2002 to 2020
$6.1M
NIGMS NIH HHS P20 GM103423NINDS NIH HHS P01 NS065719NINDS NIH HHS R01 NS043097
6 · The paper itself

Abstract

JC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML). The entry receptors for JCPyV belong to the 5-hydroxytryptamine 2 receptor (5-HT

Indexed as

Virus Internalizationbeta-ArrestinsHEK293 CellsHost-Pathogen InteractionsHumansJC VirusReceptors, Serotonin, 5-HT2Receptors, Virusbeta-ArrestinsReceptors, Serotonin, 5-HT2Receptors, Virus5-hydroxytryptamine 2 receptorCRISPR-Cas9JCPyVPMLβ-arrestin

Identifiers

PMID31091436
PMCPMC6544161

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.