ArticlePLoS neglected tropical diseases2019
Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prevalence and Mortality Outcomes of Melioidosis in Thalassemia: A Systematic Review and Meta-Analysis.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Characterization of an isogenicInfection and immunity · 2026Article
- Concurrent resistance and virulence traits in extremely drug-resistant Burkholderia pseudomallei from bovine milk samples: potential for zoonotic transmission.Veterinary research communications · 2026Article
- The Hidden Threat: Polyarticular Septic Arthritis Unmasking Disseminated Melioidosis.Journal of orthopaedic case reports · 2026Article
- BimAIJID regions · 2025Article
- Two Decades of Melioidosis in India: A Comprehensive Epidemiological Review.Pathogens (Basel, Switzerland) · 2025Review
- Genetic variation, structural analysis, and virulence implications of BimA and BimC in clinical isolates of Burkholderia pseudomallei in Thailand.Scientific reports · 2024Article
- The Predictive Factors Associated with In-Hospital Mortality of Melioidosis: A Cohort Study.Medicina (Kaunas, Lithuania) · 2024Article
- Variable Virulence Genes in Clinical Isolates ofJournal of laboratory physicians · 2023Article
- Genomic diversity of resistant and virulent factors ofFrontiers in microbiology · 2022Article
- Biogeography and genetic diversity of clinical isolates of Burkholderia pseudomallei in Sri Lanka.PLoS neglected tropical diseases · 2021Article
- The Cox model of predicting mortality among melioidosis patients in Northern Malaysia: A retrospective study.Medicine · 2021Article
- Multi locus sequence typing of clinical Burkholderia pseudomallei isolates from Malaysia.PLoS neglected tropical diseases · 2020Article
- Myanmar Burkholderia pseudomallei strains are genetically diverse and originate from Asia with phylogenetic evidence of reintroductions from neighbouring countries.Scientific reports · 2020Article
- Community-acquired bacterial pneumonia in adults: An update.The Indian journal of medical research · 2020Review
- An Evolutionary Arms Race BetweenFrontiers in microbiology · 2020Review
- Clinical Profile and Predictors of Mortality among Patients with Melioidosis.Journal of global infectious diseasesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMelioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear. METHODOLOGY/PRINCIPAL
findingsClinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity. CONCLUSION/SIGNIFICANCE: Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis.
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