ArticlePloS one2019
Development of a gastroretentive delivery system for acyclovir by 3D printing technology and its in vivo pharmacokinetic evaluation in Beagle dogs.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 91 citations in OpenAlex.
- A multi-compartment pulsatile drug delivery system for sequential release: in vitro and in vivo evaluation.Drug delivery and translational research · 2026Article
- 3D-printed dosage forms for oral administration: a review.Drug delivery and translational research · 2024Review
- Enhanced gastric residence time of acyclovir by floating raft formulation using box-behnken design.Heliyon · 2024Article
- Fused Deposition Modelling 3D-Printed Gastro-Retentive Floating Device for Propranolol Hcl Tablets.Polymers · 2023Article
- Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics.Pharmaceutics · 2023Article
- Fabrication of Gastro-Floating Famotidine Tablets: Hydroxypropyl Methylcellulose-Based Semisolid Extrusion 3D Printing.Pharmaceutics · 2023Article
- Design, preparation, andFrontiers in pharmacology · 2023Article
- Effect of Hydrophilic Polymers on the Release Rate and Pharmacokinetics of Acyclovir Tablets Obtained by Wet Granulation: In Vitro and In Vivo Assays.Molecules (Basel, Switzerland) · 2022Article
- The Evolution of the 3D-Printed Drug Delivery Systems: A Review.Pharmaceutics · 2022Review
- Development of Composite, Reinforced, Highly Drug-Loaded Pharmaceutical Printlets Manufactured by Selective Laser Sintering-In Search of Relevant Excipients for Pharmaceutical 3D Printing.Materials (Basel, Switzerland) · 2022Article
- Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication ofPolymers · 2022Article
- FDM 3D-Printed Sustained-Release Gastric-Floating Verapamil Hydrochloride Formulations with Cylinder, Capsule and Hemisphere Shapes, and Low Infill Percentage.Pharmaceutics · 2022Article
- Preparation of Acyclovir-Containing Solid Foam by Ultrasonic Batch Technology.Pharmaceutics · 2021Article
- 3D Printing of Thermo-Sensitive Drugs.Pharmaceutics · 2021Review
- Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design.AAPS PharmSciTech · 2021Article
- Process Optimization for the Continuous Production of a Gastroretentive Dosage Form Based on Melt Foaming.AAPS PharmSciTech · 2021Article
- 3DP Printing of Oral Solid Formulations: A Systematic Review.Pharmaceutics · 2021Review
- Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Design and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of Acyclovir.Nanomaterials (Basel, Switzerland) · 2020Article
- 3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease.Biomedicines · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroretentive (GR) systems are designed to prolong gastric residence time to allow sustained absorption and improve the oral bioavailability of drugs with a narrow absorption window in the upper part of the gastrointestinal tract. The present study aimed to develop a GR system for acyclovir using 3D printing technology and evaluate its in vivo pharmacokinetics after oral administration in Beagle dogs. The system consisted of a gastro-floating device, which can float in the gastric fluid, prepared by a fused deposition modeling 3D printer and conventional acyclovir sustained-release (SR) tablet. The acyclovir SR tablet was inserted to the floating device to allow sustained release of the drug in the stomach. The buoyancy and sustained-release property of the developed GR system were determined using an in vitro dissolution test, in vivo pharmacokinetic study, and abdominal X-ray imaging in Beagle dogs. The in vivo dissolution profiles of the GR system were also predicted based on the in vivo pharmacokinetic data using a population pharmacokinetic (POP-PK) model. In the dissolution test, the sustained-release characteristic of the GR system was identified with a time corresponding to 80% dissolution (T80) of 2.52 h. Following oral administration of the GR system, the time to reach the maximum concentration (Tmax) of acyclovir was significantly prolonged, whereas the maximum concentration (Cmax) decreased and the area under the curve increased compared with those obtained after the administration of immediate-release and SR tablets, indicating prolonged absorption. By X-ray imaging, we showed that the developed GR system stayed in the stomach for more than 12 h. The POP-PK model successfully described the observed plasma concentration-time data and predicted the in vivo biphasic dissolution profiles of the GR system, which was significantly different from the in vitro dissolution. The developed GR system could be applied to various drugs and had great prospects in the design and development of novel controlled-release formulations.
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