ArticleThe Journal of urology2019
Histopathology of Anterior Urethral Strictures: Toward a Better Understanding of Stricture Pathophysiology.
Article in The Journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Associations between circulating sex hormones and anterior urethral stricture disease.Translational andrology and urology · 2026Article
- Neutrophil extracellular traps in post-traumatic urethral microenvironment promote hypertrophic urethral stricture via the TLR9/NF-kB/Smad3/IL-8 axis.Apoptosis : an international journal on programmed cell death · 2026Article
- Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures.Microbiology spectrum · 2025Article
- Bacterial cellulose-based scaffold with in-situ cationic micelle modification for urethral stricture disease: Sustained drug components release, cytokines recruitment, and bacterial microenvironment regulation.Bioactive materials · 2025Article
- Urethral complications after holmium laser enucleation of the prostate are more common in patients with smaller prostates.Translational andrology and urology · 2025Article
- Development and Validation of the Length, Segment, and Etiology Anterior Urethral Stricture Disease Staging System Using Longitudinal Urethroplasty Outcomes Data From the Trauma and Urologic Reconstructive Network of Surgeons.The Journal of urology · 2025Article
- BEES-HAUS preventing urethral stricture recurrence by restoring the integrity of urothelium and its further simplified version, the BHES-HAUS.Frontiers in bioengineering and biotechnology · 2025Article
- Efficacy of transurethral plasmakinetic resection of the prostate using a small-caliber resectoscope for benign prostatic hyperplasia with mild urethral stricture.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Deep Phenotyping the Anterior Urethral Stricture: Characterizing the Relationship Between Inflammation, Fibrosis, Patient History, and Disease Pathophysiology.The Journal of urology · 2024Article
- Investigation of risk factors in the development of recurrent urethral stricture after internal urethrotomy.World journal of clinical cases · 2024Article
- Machine learning algorithm predicts urethral stricture following transurethral prostate resection.World journal of urology · 2024Article
- Wound healing responses of urinary extravasation after urethral injury.Scientific reports · 2023Article
- DKK1 Ameliorates Myofibroblast Differentiation in Urethral Fibrosis in Vivo and in Vitro by Regulating the Canonical Wnt Pathway.International journal of medical sciences · 2023Article
- In search of the ideal animal model for urethral strictures for therapeutic purposes.Translational andrology and urology · 2022Article
- Does aetiology of urethral stricture influence the survival of the buccal mucosa graft?-comparative study in patients with penile urethral stricture due to lichen sclerosusTranslational andrology and urology · 2022Article
- Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture.International journal of molecular sciences · 2022Review
- The contribution of the immune system to genitourinary fibrosis.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- A novel stricture prevention technique in blunt urethral injury: A multi-center retrospective observational study.Investigative and clinical urology · 2022Observational
- Histopathologic and clinical comparison of recurrent and non-recurrent urethral stricture disease treated by reconstructive surgery.Translational andrology and urology · 2021Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
purposeHistopathology can provide insights into disease mechanisms but to date it has been poorly described for urethral stricture. The purpose of this study was to comprehensively describe histopathological findings of stricture specimens obtained at the time of anterior urethroplasty. MATERIALS AND
methodsAll pathological specimens of men who underwent anterior urethroplasty of urethral stricture disease from 2010 to 2017 at a single institution were rereviewed by a single blinded pathologist directed to rule out lichen sclerosus and then describe inflammatory cell type and severity when present. Cohorts comprising strictures with no inflammation, minimal to mild inflammation or moderate to severe inflammation were developed and stricture, patient and surgical outcome characteristics were compared.
resultsHistopathology slides from 100 anterior urethroplasty cases were reviewed. Two or more lichen sclerosus characteristics were present in 21% of specimens and 44% of specimens showed chronic inflammation, which was minimal in 20%, mild in 39%, moderate in 39% and severe in 2%. Lymphocytes in 86% of specimens and plasma cells in 12% were the predominant cell types. Patients with inflammatory stricture reported worse overall health. Inflammation was largely absent from isolated bulbomembranous strictures (9%) and more common in lichen sclerosus strictures (100%). The 11% overall failure rate was not affected by the presence (7%) or absence (14%) of inflammation.
conclusionsChronic inflammation is prevalent in a significant percent of urethral stricture disease specimens. Associations with worse overall health suggest systemic mediators. Absent inflammation in bulbomembranous strictures suggests a unique pathophysiology in this region. The presence of inflammation did not affect surgical outcomes at mid-term followup.
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