Evidence map›Paper›PMID 31091162›Full record

ArticleMolecular biology of the cell2019

AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca

Jonathan G Murphy, Kevin C Crosby, Philip J Dittmer, William A Sather, Mark L Dell'Acqua

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. CRAC channels as targets for immunotherapy.Current opinion in immunology · 2026
    Review
  2. Stimulation of CaScience signaling · 2025
    Article
  3. Review
  4. House dust mite allergens, store-operated CaThe Journal of physiology · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. A cellular atlas of calcineurin signaling.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  9. The CaNeuropharmacology · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. R-type voltage-gated CaCell reports · 2022
    Article
  14. Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Review
  16. Near-UV Light Induced ROS Production Initiates Spatial CaInternational journal of molecular sciences · 2021
    Article
  17. The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jonathan G MurphyEunice Kennedy Shriver Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Kevin C CrosbyDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.
Philip J DittmerDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.
William A SatherDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.
University of Colorado Denver · USNational Institutes of Health · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Mechanisms of Neuronal Calcineurin-NFAT Synapse-to-Nucleus SignalingR01MH102338 · NIMH · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2014 to 2019
$2.2M
NCATS NIH HHS UL1 TR001082NIMH NIH HHS R01 MH102338NINDS NIH HHS P30 NS048154
6 · The paper itself

Abstract

In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca

Indexed as

Signal TransductionA Kinase Anchor ProteinsAmino Acid MotifsAnimalsCalcineurinCalcium Channels, L-TypeCalcium SignalingCell LineCell NucleusCells, CulturedCyclic AMP-Dependent Protein KinasesDendritic SpinesHippocampusModels, BiologicalNeuronsNFATC Transcription FactorsAKAP5 protein, humanA Kinase Anchor ProteinsCalcineurinCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesNFATC Transcription Factors

Identifiers

PMID31091162
PMCPMC6727748
OpenAlexW2945474486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.