Evidence map›Paper›PMID 31091161›Full record

ArticleMolecular biology of the cell2019

Spindle-F-actin interactions in mitotic spindles in an intact vertebrate epithelium.

Angela M Kita, Zachary T Swider, Ivan Erofeev, Mary C Halloran, Andrew B Goryachev, William M Bement

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
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  10. FAM110A promotes mitotic spindle formation by linking microtubules with actin cytoskeleton.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
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  15. Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Cytoskeletal control of early mammalian development.Nature reviews. Molecular cell biology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Angela M KitaCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI 53706.
Zachary T SwiderCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI 53706.
Ivan ErofeevCentre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh EH9 3JD, United Kingdom.
Mary C HalloranDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI 53706.
Andrew B GoryachevCentre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh EH9 3JD, United Kingdom.
William M BementCellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, WI 53706.
University of Wisconsin–Madison · USUniversity of Edinburgh · GB

Funding

Transient cytoskeletal arraysR01GM052932 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BEMENT, WILLIAM · 1997 to 2023
$7.2M
Regulation of protein targeting in axon guidance and neuronal morphogenesisR01NS086934 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 2015 to 2018
$1.3M
Biotechnology and Biological Sciences Research Council BB/P006507Biotechnology and Biological Sciences Research Council BB/P01190XNIGMS NIH HHS R01 GM052932NINDS NIH HHS R01 NS086934
6 · The paper itself

Abstract

Mitotic spindles are well known to be assembled from and dependent on microtubules. In contrast, whether actin filaments (F-actin) are required for or are even present in mitotic spindles has long been controversial. Here we have developed improved methods for simultaneously preserving F-actin and microtubules in fixed samples and exploited them to demonstrate that F-actin is indeed associated with mitotic spindles in intact

Indexed as

ActinsAnimalsCell SurvivalEndoplasmic ReticulumEpithelial CellsEpitheliumForminsSpindle ApparatusSpindle PolesXenopus laevisActinsFormins

Identifiers

PMID31091161
PMCPMC6727749
OpenAlexW2946334536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.