ArticleJournal of neurophysiology2019
Differential effects of aging and physical activity on corticospinal excitability of upper and lower limb muscles.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077460 (Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Intersegmental Modulation of Lower-Limb Corticospinal Excitability and Inhibition Induced by Upper-Limb Isometric Contractions: A Systematic Review.The European journal of neuroscience · 2026Pooled it
- Neural Plasticity in Spinal and Corticospinal Pathways Induced by Balance Training in Neurologically Intact Adults: A Systematic Review.Frontiers in human neuroscience · 2022Pooled it
- Sex-related differences in fractionated reaction time are not related to corticospinal excitability and inhibition.European journal of applied physiology · 2026Article
- Sex-related differences in corticospinal excitability and inhibition of upper and lower limb muscles.European journal of applied physiology · 2026Article
- Resting motor threshold in navigated transcranial magnetic stimulation: relationship between inter-individual variance and distinct clinical and anatomical factors.Acta neurochirurgica · 2025Article
- Assessing age-related proprioceptive changes through active and passive tasks: implications for stroke assessment.Journal of neural engineering · 2025Article
- Age-related increase in the excitability of mouse layer V pyramidal neurons in the primary motor cortex is accompanied by an increased persistent inward current.GeroScience · 2025Article
- Age-related differences in agility are related to both muscle strength and corticospinal tract function.Physiological reports · 2025Article
- Characteristics of motor evoked potentials in patients with peripheral vascular disease.PloS one · 2024Article
- Home-based arm cycling exercise improves trunk control in persons with incomplete spinal cord injury: an observational study.Scientific reports · 2023Observational
- Considerable effects of lateralization and aging in intracortical excitation and inhibition.Frontiers in neuroscience · 2023Article
- Use-dependent corticospinal excitability is associated with resilience and physical performance during simulated military operational stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Motor cortex plasticity and visuomotor skill learning in upper and lower limbs of endurance-trained cyclists.European journal of applied physiology · 2022Article
- Physical activity, motor performance and skill learning: a focus on primary motor cortex in healthy aging.Experimental brain research · 2021Review
- Input-output slope curve estimation in neural stimulation based on optimal sampling principlesJournal of neural engineering · 2021Article
- Age-Related Differences in Corticospinal Excitability and Anticipatory Postural Adjustments of the Trunk.Frontiers in aging neuroscience · 2021Article
- The Dynamic Motor Control Index as a Marker of Age-Related Neuromuscular Impairment.Frontiers in aging neuroscience · 2021Article
- Attenuated activation of knee extensor muscles during fast contractions in older men and women.European journal of applied physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Corticospinal tract excitability can be altered by age, physical activity (PA), and possibly sex, but whether these effects differ between upper and lower limb muscles is unknown. We determined the influence of age, PA, and sex on corticospinal excitability of an upper limb and a lower limb muscle during submaximal contractions by comparing stimulus-response curves of motor evoked potentials (MEPs). Transcranial magnetic stimulation (TMS) was used to evoke stimulus-response curves in active muscles by incrementally increasing the stimulator intensity from below the active motor threshold (AMT) until a plateau in MEP amplitudes was achieved. Stimulus-response curves were analyzed from the first dorsal interosseous (FDI) of 30 young (23.9 ± 3.8 yr) and 33 older (72.6 ± 5.6 yr) men and women and the vastus lateralis (VL) of 13 young (23.2 ± 2.2 yr) and 25 older (72.7 ± 5.5 yr) men and women. Corticospinal excitability was determined by fitting the curves with a four-parameter sigmoidal curve and calculating the maximal slope (slope
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.