Evidence map›Paper›PMID 31091152›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity.

Jian Cui, Rachel C Drew, Matthew D Muller, Cheryl Blaha, Virginia Gonzalez, Lawrence I Sinoway

Erratum issuedAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Sympathetic transduction in humans: recent advances and methodological considerations.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jian CuiPenn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Rachel C DrewPenn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.ORCID 0000-0001-8001-1946
Matthew D MullerPenn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.ORCID 0000-0002-7411-8816
Cheryl BlahaPenn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Virginia GonzalezPenn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Lawrence I SinowayPenn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

Smoking is a risk factor for cardiovascular diseases. Prior reports showed a transient increase in blood pressure (BP) following a spontaneous burst of muscle sympathetic nerve activity (MSNA). We hypothesized that this pressor response would be accentuated in smokers. Using signal-averaging techniques, we examined the BP (Finometer) response to MSNA in 18 otherwise healthy smokers and 42 healthy nonsmokers during resting conditions. The sensitivities of baroreflex control of MSNA and heart rate were also assessed. The mean resting MSNA, heart rate, and mean arterial pressure (MAP) were higher in smokers than nonsmokers. The MAP increase following a burst of MSNA was significantly greater in smokers than nonsmokers (Δ3.4 ± 0.3 vs. Δ1.6 ± 0.1 mmHg,

Indexed as

AdultArterial PressureBaroreflexBlood PressureCigarette SmokingFemaleHeart RateHumansHypertensionMaleMuscle, SkeletalSympathetic Nervous SystemVasoconstrictor AgentsVasoconstrictor Agentsbaroreceptorhemodynamicsnervous systemsmokersympathetic

Identifiers

PMID31091152
PMCPMC6732427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.