ReviewJBRA assisted reproduction2019
Ethiopathogenic mechanisms of endometriosis-related infertility.
Review in JBRA assisted reproduction, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Gut Microbiota Alterations and Reproductive Tract Dysbiosis in Endometriosis: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Endometriosis Is Associated with Increased Serum and Peritoneal Fluid Concentrations of Chromogranin A and Its Derivatives.Journal of clinical medicine · 2026Article
- Association of Peripheral Inflammatory Markers with Conception Outcomes Among Women with Endometriosis-Associated Infertility.Diagnostics (Basel, Switzerland) · 2026Article
- Analysis of risk factors compromising embryo quality and quantity in patients with endometriosis.Frontiers in medicine · 2026Article
- Immune dysregulation in endometriosis: the T cell perspective.Frontiers in immunology · 2026Review
- Cumulative live birth rates under three consecutive IVF/ICSI treatment cycles are reduced in women with endometriosis and/or adenomyosis diagnosed by ultrasonography.Human reproduction (Oxford, England) · 2025Article
- Systemic Immune and Tumor Marker Profiles in Ovarian and Deep Infiltrating Endometriosis: Associations with Disease Severity and Symptom Burden.International journal of molecular sciences · 2025Article
- The Translation and Cross-Cultural Adaptation of The Persian Version of The WERF EPHect Endometriosis Patient Questionnaire: A Cross-Sectional Study.International journal of fertility & sterility · 2025Article
- Association of Bioavailable 25(OH)D Levels With Endometriosis in Infertile Bangladeshi Women: A Cross-Sectional Study.Health science reports · 2025Article
- The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications.International journal of molecular sciences · 2025Review
- Association between dietary selenium intake and endometriosis risk: a cross-sectional analysis.Frontiers in endocrinology · 2025Article
- Decreased expression ofInternational journal of reproductive biomedicine · 2024Article
- Comparison of success rates in early stages of in vitro fertilization (IVF) in women with and without endometriosis.Narra J · 2024Article
- How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study.Reproductive health · 2024Article
- Correlation of Glycolysis-immune-related Genes in the Follicular Microenvironment of Endometriosis Patients with ART Outcomes.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.The Journal of endocrinology · 2024Article
- Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.Cell reports. Medicine · 2024Article
- Downregulation of lncRNA LINC01465 predicts ovarian endometriosis and its prognosis.Wiener klinische Wochenschrift · 2024Article
- A Comprehensive Review of the Efficacy and Safety of Dopamine Agonists for Women with Endometriosis-associated Infertility from Inception to July 31, 2022.Acta medica Philippina · 2024Article
- Primer on Female Infertility for the Reproductive Urologist.Urology research & practice · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis is a highly prevalent disease among women of reproductive age and is frequently associated to infertility. However, the mechanisms underlying endometriosis-related infertility are still not completely known. Several studies have been conducted in order to elucidate this question. Besides anatomical changes that may impair gametes and embryo transport along the tubes; a smaller ovarian reserve due to advanced endometriosis and endometriomas; and a dysregulated hypothalamic-pituitary-ovarian axis, there are pieces of evidence suggesting that the peritoneal ectopic endometrial foci may induce a local inflammatory response, with the recruitment of macrophages, cytokine release, and reactive oxygen species generation, leading to a pro-oxidant peritoneal microenvironment. These alterations may be systemically reflected and also affect the follicular microenvironment. A harmful follicular fluid may disrupt cumulus cells functions and, consequently, compromise oocyte competence. There is also evidence suggesting that the peritoneal fluid of women with endometriosis may alter sperm function. Reduced endometrial receptivity is also pointed as a possible mechanism involved in endometriosis-related infertility, which needs further investigation.
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