Evidence map›Paper›PMID 31090971›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

A Rhenium Isonitrile Complex Induces Unfolded Protein Response-Mediated Apoptosis in Cancer Cells.

A Paden King, Sierra C Marker, Robert V Swanda, Joshua J Woods, Shu-Bing Qian, Justin J Wilson

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Synthesis of aACS omega · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Naphthalene Exchange in [Re(ηChemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  15. Review
  16. Article
  17. Unveiling Luminescent IrChemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A Paden KingDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Sierra C MarkerDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
Robert V SwandaDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Joshua J WoodsDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0002-6213-4093
Shu-Bing QianDivision of Nutritional Sciences, Cornell University, Ithaca, NY, 14853, USA.
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.ORCID http://orcid.org/0000-0002-4086-7982

Funding

CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
O-GlcNAc Signaling in Translational Control of Stress ResponseR01GM122814 · NIGMS · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2017 to 2020
$1.3M
Dynamic mRNA m6A modification in oncogenic translationR21CA227917 · NCI · CORNELL UNIVERSITY · PI QIAN, SHU-BING · 2018 to 2019
$371k
Howard Hughes Medical Institute 55108556National Institute of Health R01GM1222814National Institute of Health R21CA227917National Institute of Health T32GM008500National Science Foundation CHE-1531632National Science Foundation DGE-1650441NCI NIH HHS R21 CA227917NIGMS NIH HHS R01 GM122814NIGMS NIH HHS T32 GM008500US Department of Defense W81XWH-17-1-0097
6 · The paper itself

Abstract

Complexes of the element Re have recently been shown to possess promising anticancer activity through mechanisms of action that are distinct from the conventional metal-based drug cisplatin. In this study, we report our investigations on the anticancer activity of the complex [Re(CO)

Indexed as

ApoptosisCell Line, TumorCoordination ComplexesCrystallography, X-RayDrug Resistance, NeoplasmEukaryotic Initiation Factor-2HEK293 CellsHumansMolecular ConformationNitrilesPhosphorylationRheniumTranscription Factor CHOPUnfolded Protein ResponseUp-RegulationCoordination ComplexesDDIT3 protein, humanEukaryotic Initiation Factor-2NitrilesRheniumTranscription Factor CHOPbioinorganic chemistrycancerendoplasmic reticulum stressmetallodrugstranslation inhibition

Identifiers

PMID31090971
PMCPMC6625872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.