Evidence map›Paper›PMID 31090693›Full record

ArticleOptics letters2019

In vivo thickness measurement of the lipid layer and the overall tear film by interferometry.

Yuqiang Bai, Jason J Nichols

Abstract read
In one paragraph

Article in Optics letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Validation of a new objective method to assess lipid layer thickness without the need of an interferometer.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuqiang Bai
Jason J Nichols

Funding

The role of (O-acyl)-omega-hydroxy fatty acids in human lipid layer structure and function in health and meibomian gland dysfunction.R01EY026947 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NICHOLS, JASON JAY · 2016 to 2020
$1.8M
NEI NIH HHS R01 EY026947
6 · The paper itself

Abstract

New approaches for the simultaneous measurement of the thickness of the lipid layer (LL) and overall tear film (TF) in vivo are needed. In the current research, the interference signal from the ocular surface was analyzed and simplified as the superposition of two sinusoidal functions. One function with low frequency was modulated by LL, and the other function with high frequency was modulated by precorneal TF (PCTF). Two sinusoidal functions were separated and analyzed to retrieve the thickness of LL and PCTF. To validate the feasibility of the approach, a customized fiber-based interferometer with a related data processing program was developed and tested in vivo.

Identifiers

PMID31090693
PMCPMC7029674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.