Evidence map›Paper›PMID 31090542›Full record

ArticleeLife2019

Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation.

Helen Strutt, Jessica Gamage, David Strutt

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  15. Core planar cell polarity genesProceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Helen StruttDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0003-4365-2271
Jessica GamageDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
David StruttDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0001-8185-4515
University of Sheffield · GB

Funding

Medical Research Council G0900203-1/1Medical Research Council G1000405-1/1The Wellcome Trust 100986/Z/13/ZThe Wellcome Trust 210630/Z/18/ZWellcome Trust 100986/Z/13/ZWellcome Trust 210630/Z/18/Z
6 · The paper itself

Abstract

The conserved core planar polarity pathway is essential for coordinating polarised cell behaviours and the formation of polarised structures such as cilia and hairs. Core planar polarity proteins localise asymmetrically to opposite cell ends and form intercellular complexes that link the polarity of neighbouring cells. This asymmetric segregation is regulated by phosphorylation through poorly understood mechanisms. We show that loss of phosphorylation of the core protein Strabismus in the

Indexed as

Cell PolarityAnimalsCasein Kinase 1 epsilonDishevelled ProteinsDrosophila melanogasterDrosophila ProteinsMembrane ProteinsPhosphorylationProtein Processing, Post-TranslationalProtein TransportPupaWings, AnimalCasein Kinase 1 epsilonDishevelled ProteinsDrosophila ProteinsMembrane ProteinsVang protein, DrosophilaCasein Kinase Iεdevelopmental biologyDishevelledD. melanogasterPCPphosphorylationplanar cell polarityStrabismus

Identifiers

PMID31090542
PMCPMC6542583
OpenAlexW2946069141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.