ArticleeLife2019
IFNγ induces epigenetic programming of human T-bet
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Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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125citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
125 citing papers in PubMed, 169 citations in OpenAlex.
- Elevated CD21Journal of clinical immunology · 2022Trial
- The Antigen Presenting Potential of CD21Frontiers in immunology · 2020Trial
- Identification of a systemic lupus erythematosus disease signature in resting naive B cells.The Journal of clinical investigation · 2026Article
- Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis.Cardiovascular research · 2026Article
- Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.Immunological reviews · 2026Review
- Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis.Hepatology communications · 2026Article
- Interferon-Mediated Regulation of Memory B Cell Identity and Function.Immunological reviews · 2026Review
- Age-Associated B Cells: Origins, Regulation, and Tissue-Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases.Immunological reviews · 2026Review
- The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments.Immunological reviews · 2026Review
- Autoreactive B cells in systemic lupus erythematosus: insights from integrative multi-omics analyses.Inflammation and regeneration · 2026Review
- Human CD21Journal of human immunity · 2026Review
- Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE.Lupus science & medicine · 2026Article
- Genetic and epigenetic underpinnings of biological aging: a multi-omics study integrating Mendelian randomization, spatial transcriptomics, and drug target discovery.Clinical epigenetics · 2026Article
- Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes.Cell reports · 2026Article
- Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus.Nature reviews. Rheumatology · 2026Review
- Atypical memory B cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19.JCI insight · 2026Article
- Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS-CoV-2 Vaccination.European journal of immunology · 2026Article
- Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation.bioRxiv : the preprint server for biology · 2026Article
- IFNγ-induced IRF1 synergizes with TLR7 signals to tune the IRF4-IRF8 axis and drive pathogenic effector B cell fate.bioRxiv : the preprint server for biology · 2026Article
- Could belimumab be a new weapon in autoimmune complicated CVID?Frontiers in immunology · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Esther ZumaqueroDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0002-7631-7114
Sara L StoneDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0002-1689-8148
Christopher D ScharerDepartment of Microbiology and Immunology, Division of Rheumatology, Emory University, Atlanta, United States.ORCID 0000-0001-7716-8504
Scott A JenksDepartment of Medicine, Division of Rheumatology, Emory University, Atlanta, United States.
Anoma NelloreDepartment of Medicine, Division of Infectious Disease, The University of Alabama at Birmingham, Birmingham, United States.
Betty MousseauDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.
Antonio Rosal-VelaDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.
Davide BottaDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0003-3926-0662
John E BradleyDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, United States.
Wojciech WojciechowskiCenter for Pediatric Biomedical Research, Flow Cytometry Shared Resource Laboratory, University of Rochester School of Medicine and Dentistry, Rochester, United States.
Travis PtacekDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.
Maria I DanilaDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, United States.
Jeffrey C EdbergDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, United States.
S Louis BridgesDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, United States.
Robert P KimberlyDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, United States.
W Winn ChathamDepartment of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, United States.
Trenton R SchoebDepartment of Genetics, Animal Resources Program, The University of Alabama at Birmingham, Birmingham, United States.
Alexander F RosenbergDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.
Jeremy M BossDepartment of Microbiology and Immunology, Division of Rheumatology, Emory University, Atlanta, United States.
Ignacio SanzDepartment of Medicine, Division of Rheumatology, Emory University, Atlanta, United States.
Frances E LundDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, United States.ORCID 0000-0003-3083-1246
University of Alabama at Birmingham · USEmory University · USUniversity of Rochester · US
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9MVirology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1MRegulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2014 to 2026
$76.6MNational Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6MUAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4MRegulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2MUAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MVirus-induced Cell Fate Decisions in Anti-Viral ImmunityU19AI109962 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2014 to 2018
$11.6MRole of B Cells in Synovial Inflammation & LN Remodeling in RA ArthritisP01AI078907 · NIAID · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2010 to 2014
$10.8MROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0MNCATS NIH HHS UL1 TR001417NCATS NIH HHS UL1 TR003096NCI NIH HHS P30 CA013148NCI NIH HHS UM1 CA183728NCRR NIH HHS G20 RR022807NIAID NIH HHS P01 AI078907NIAID NIH HHS P01 AI125180NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI110508NIAID NIH HHS R01 AI123733NIAID NIH HHS R37 AI049660NIAID NIH HHS U19 AI109962NIAID NIH HHS U19 AI110483NIAMS NIH HHS K23 AR062100NIAMS NIH HHS P30 AR048311NIDDK NIH HHS P30 DK079337NIGMS NIH HHS T32 GM008361NIGMS NIH HHS T32 GM008490NIH HHS 1P30 DK079337NIH HHS K23 AR062100NIH HHS P01 AI078907NIH HHS P01 AI125180NIH HHS R01 AI110508NIH HHS R01 AI123733NIH HHS R37 AI049660NIH HHS T32 GM008361NIH HHS U19 AI110483NIH HHS UL1 TR001417
Abstract
Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show that elevated levels of IFNγ in SLE patients correlate with expansion of the T-bet expressing IgD
Indexed as
Cell DifferentiationEpigenesis, GeneticB-Lymphocyte SubsetsGene Regulatory NetworksHumansInterferon-gammaInterleukin-21InterleukinsLupus Erythematosus, SystemicT-bet Transcription FactorT-Box Domain ProteinsToll-Like Receptor 7Toll-Like Receptor 8Interferon-gammaInterleukin-21InterleukinsT-bet Transcription FactorT-Box Domain ProteinsToll-Like Receptor 7Toll-Like Receptor 8antibody secreting cellsB lymphocyteshumanimmunologyinflammationinterferonsmousesystemic lupus erythematosusT-bet
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.