Evidence map›Paper›PMID 31090470›Full record

ArticleDrug delivery2019

Co-delivery of metformin and levofloxacin hydrochloride using biodegradable thermosensitive hydrogel for the treatment of corneal neovascularization.

Dong Liu, Qianni Wu, Yuqiong Zhu, Yijun Liu, Xiuli Xie, Sihan Li, Haotian Lin, Weirong Chen, Fangming Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dong Liua GDHPPCLab, School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
Qianni Wub State Key Laboratory of Ophthalmology , Zhongshan Ophthalmic Center, Sun Yat-Sen University , Guangzhou , China.
Yuqiong Zhua GDHPPCLab, School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
Yijun Liua GDHPPCLab, School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
Xiuli Xiea GDHPPCLab, School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
Sihan Lia GDHPPCLab, School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
Haotian Linb State Key Laboratory of Ophthalmology , Zhongshan Ophthalmic Center, Sun Yat-Sen University , Guangzhou , China.
Weirong Chenb State Key Laboratory of Ophthalmology , Zhongshan Ophthalmic Center, Sun Yat-Sen University , Guangzhou , China.
Fangming Zhua GDHPPCLab, School of Chemistry , Sun Yat-Sen University , Guangzhou , China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Corneal neovascularization (CNV) is one of the major causes of severe disorders in ocular surface. Subconjunctival administration provides a localized and effective delivery of anti-angiogenic agents to inhibit neovascularization. In the present study, the ABA triblock copolymer of poly(D,L-lactic-co-glycolic acid)-block-poly(ethylene glycol)-block-poly(D,L-lactic-co-glycolic acid) (PLGA-PEG-PLGA) was used as a sustained drug delivery carrier for metformin (MET) and levofloxacin hydrochloride (LFH). Both drugs and PLGA-PEG-PLGA copolymers could be easily dissolved in water at low or room temperature and the mixed solution could form a drug-loaded thermosensitive hydrogel in terms of body temperature response. The in vitro release investigation displayed a sustained release of MET and LFH from the formulation for one month. The in vivo efficacy of subconjunctival injection of the MET + LFH loaded thermosensitive hydrogel in inhibiting CNV was evaluated on a mouse model of corneal alkali burn. Compared with the single administration of MET or LFH loaded thermosensitive hydrogel, the MET + LFH loaded thermosensitive hydrogel remarkably inhibited the formation of CNV. The sustained release of MET and an antibiotic (LFH) provides synergistic therapeutic outcome. As a result, the co-delivery of MET and LFH using PLGA-PEG-PLGA thermosensitive hydrogel by subconjunctival injection has great potential for ocular anti-angiogenic therapy.

Indexed as

Angiogenesis InhibitorsAnimalsBiocompatible MaterialsCell SurvivalCorneal NeovascularizationDrug CarriersDrug CombinationsDrug LiberationFemaleHydrogelsInjections, IntraocularLevofloxacinMaleMetforminMice, Inbred C57BLPolyethylene GlycolsAngiogenesis InhibitorsBiocompatible MaterialsDrug CarriersDrug CombinationsHydrogelsLevofloxacinMetforminPolyethylene GlycolsPolyglactin 910poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid)corneal neovascularizationmetforminsubconjunctival injectionsynergistic effectThermosensitive hydrogel

Identifiers

PMID31090470
PMCPMC6534255
OpenAlexW2944987998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.