Evidence map›Paper›PMID 31090424›Full record

ArticleJournal of proteome research2019

Fabric Phase Sorptive Extraction-A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment.

Alexandra Taraboletti, Maryam Goudarzi, Abuzar Kabir, Bo-Hyun Moon, Evagelia C Laiakis, Jerome Lacombe, Pelagie Ake, Sueoka Shoishiro, David Brenner, Albert J Fornace and 1 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexandra TarabolettiORCID 0000-0002-8779-483X
Maryam GoudarziLerner Research Institute , Cleveland Clinic Foundation , 9500 Euclid Avenue , Cleveland , Ohio 44195 , United States.
Abuzar KabirInternational Forensic Research Institute, Department of Chemistry and Biochemistry , Florida International University , 11200 Southwest Eighth Street , Miami , Florida 33199 , United States.
Bo-Hyun Moon
Evagelia C LaiakisORCID 0000-0002-4924-9013
Jerome LacombeCenter for Applied NanoBiosience and Medicine , University of Arizona , 475 North Fifth Street , Phoenix , Arizona 85004 , United States.
Pelagie Ake
Sueoka ShoishiroCenter for Applied NanoBiosience and Medicine , University of Arizona , 475 North Fifth Street , Phoenix , Arizona 85004 , United States.
David BrennerCenter for Radiological Research , Columbia University , 630 West 168th Street , New York , New York 10032 , United States.
Albert J Fornace
Frederic ZenhausernCenter for Applied NanoBiosience and Medicine , University of Arizona , 475 North Fifth Street , Phoenix , Arizona 85004 , United States.

Funding

Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORNACE, ALBERT J · 2005 to 2024
$105.4M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
TRAINING GRANT IN TUMOR BIOLOGYT32CA009686 · NCI · GEORGETOWN UNIVERSITY · PI ANNA Tate RIEGEL, DAVID J ROBBINS · 1996 to 2026
$10.8M
Targeted Biomarker Panels and Pre-processing Device for the Rapid Assessment of Radiation Injury in Easily Accessible BiofluidsU01AI148307 · NIAID · GEORGETOWN UNIVERSITY · PI LAIAKIS, EVAGELIA CHRISTOS, ZENHAUSERN, FREDERIC · 2021 to 2025
$2.9M
NCI NIH HHS P30 CA051008NCI NIH HHS T32 CA009686NIAID NIH HHS U01 AI148307NIAID NIH HHS U19 AI067773
6 · The paper itself

Abstract

The modern application of mass spectrometry-based metabolomics to the field of radiation assessment and biodosimetry has allowed for the development of prompt biomarker screenings for radiation exposure. Our previous work on radiation assessment, in easily accessible biofluids (such as urine, blood, saliva), has revealed unique metabolic perturbations in response to radiation quality, dose, and dose rate. Nevertheless, the employment of swift injury assessment in the case of a radiological disaster still remains a challenge as current sample processing can be time consuming and cause sample degradation. To address these concerns, we report a metabolomics workflow using a mass spectrometry-compatible fabric phase sorptive extraction (FPSE) technique. FPSE employs a matrix coated with sol-gel poly(caprolactone-

Indexed as

BiomarkersChromatography, LiquidHumansMass SpectrometryMetabolomeMetabolomicsRadiation ExposureRadiation, IonizingRadiometryBiomarkersbiodosimetryextractionfabric phase sorptive extractionmetabolite stabilitymetabolomicsradiationuntargeted metabolomicswhole blood extraction

Identifiers

PMID31090424
PMCPMC7437658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.