Evidence map›Paper›PMID 31090267›Full record

ReviewJournal of Zhejiang University. Science. B2019

Bile-ology: from bench to bedside.

Li-Hua Jin, Zhi-Peng Fang, Min-Jie Fan, Wen-Dong Huang

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Bile acid signaling, metabolism, and aging.Liver research (Beijing, China) · 2026
    Review
  2. Review
  3. Review
  4. The advantages ofFuture microbiology · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. NADAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2022
    Review
  11. Article
  12. Bile acid transporter-mediated oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Li-Hua JinDepartment of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Zhi-Peng FangDepartment of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Min-Jie FanCollege of Life Science, Zhejiang University, Hangzhou 310058, China.
Wen-Dong HuangDepartment of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
City of Hope · USXiamen University · CNZhejiang University · CN

Funding

MiRNAs in hepatocellular carcinoma development and treatmentR01CA139158 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HUANG, WENDONG, YU, HUA E · 2011 to 2021
$3.7M
NCI NIH HHS R01 CA139158
6 · The paper itself

Abstract

Bile acids (BAs) are originally known as detergents essential for the digestion and absorption of lipids. In recent years, extensive research has unveiled new functions of BAs as gut hormones that modulate physiological and pathological processes, including glucose and lipid metabolism, energy expenditure, inflammation, tumorigenesis, cardiovascular disease, and even the central nervous system in addition to cholesterol homeostasis, enterohepatic protection and liver regeneration. BAs are closely linked with gut microbiota which might explain some of their crucial roles in organs. The signaling actions of BAs can also be mediated through specific nuclear receptors and membrane-bound G protein-coupled receptors. Several pharmacological agents or bariatric surgeries have demonstrated efficacious therapeutic effects on metabolic diseases through targeting BA signaling. In this mini-review, we summarize recent advances in bile-ology, focusing on its translational studies.

Indexed as

AnimalsBile Acids and SaltsCarcinogenesisCholesterolDetergentsDiabetes Mellitus, Type 2Drug DiscoveryGastrointestinal MicrobiomeHomeostasisHumansInflammationInflammatory Bowel DiseasesLipid MetabolismLipidsMetabolic DiseasesMiceBile Acids and SaltsCholesterolDetergentsLipidsReceptors, Cytoplasmic and NuclearBile acid; Gut microbiota; Farnesoid X receptor; G protein-coupled bile acid receptor; Metabolic disease

Identifiers

PMID31090267
PMCPMC6568232
OpenAlexW2945604825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.